caa a22 4500 445887745 CHVBK 20180317145604.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0289-2 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0289-2 Endoscopic and histopathological characteristics suggesting the presence of gastric mucosal high grade neoplasia foci in cases initially diagnosed as gastric mucosal low grade neoplasia by forceps biopsy in Korea [Elektronische Daten] [Byung-Hoon Min, Kyoung-Mee Kim, Eun Kim, Cheol Park, Jae Kim, Hyuk Lee, Jun Lee, Dong Chang, Young-Ho Kim, Poong-Lyul Rhee, Jong Rhee] Background: As biopsy sites may miss coexisting gastric mucosal high grade neoplasia (HGN) foci, making a diagnosis of gastric mucosal low grade neoplasia (LGN) based only on forceps biopsy specimens can be inaccurate. Therefore, to achieve an accurate diagnosis, endoscopic mucosal resection (EMR) of the entire lesion is required. However, EMR can cause serious complications such as perforation or bleeding. Considering these points, it is necessary to identify the characteristics suggesting coexisting HGN foci in cases initially diagnosed as LGN by forceps biopsy. Methods: Three hundred and five lesions from 282 consecutive patients were initially diagnosed as LGN by forceps biopsy and later resected using EMR. The still photographs from endoscopies and pathology slides of these lesions were reviewed. Results: After EMR, 272 lesions (89.2%) were finally diagnosed as LGN and 33 lesions (10.8%) were diagnosed as having HGN foci, including 1 intramucosal carcinoma. Univariate analysis showed that lesions >1.0cm on endoscopy and lesions with tubulovillous or villous histology on forceps biopsy specimens were significantly more frequently found in cases with HGN than in LGN cases. Multivariate analysis demonstrated that lesion size >1.0cm on endoscopy and findings of tubulovillous or villous histology on forceps biopsy specimens were independent risk factors for coexisting HGN foci in cases initially diagnosed as LGN by forceps biopsy. Conclusions: If the lesions diagnosed as LGN by forceps biopsy are >1.0cm on endoscopy or show tubulovillous or villous histology, EMR might be considered to avoid the risk of missing HGN foci. Springer, 2010 Gastric mucosal low grade neoplasia nationallicence Gastric mucosal high grade neoplasia nationallicence Endoscopic mucosal resection nationallicence Forceps biopsy nationallicence Min Byung-Hoon Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Kim Kyoung-Mee Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710, Seoul, Korea aut Kim Eun Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Park Cheol Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710, Seoul, Korea aut Kim Jae Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Lee Hyuk Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut Lee Jun Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Chang Dong Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Kim Young-Ho Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Rhee Poong-Lyul Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Rhee Jong Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 17-24 0944-1174 46:1<17 2011 46 535 https://doi.org/10.1007/s00535-010-0289-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0289-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Min Byung-Hoon Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyoung-Mee Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Eun Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Park Cheol Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jae Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Hyuk Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jun Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Chang Dong Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Young-Ho Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Rhee Poong-Lyul Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Rhee Jong Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 17-24 0944-1174 46:1<17 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer