caa a22 4500 445887869 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00535-011-0396-8 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0396-8 The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk [Elektronische Daten] [Mitsuru Kaise, Jun Miwa, Jun Tashiro, Yasukazu Ohmoto, Shingo Morimoto, Masayuki Kato, Mitsuyoshi Urashima, Masahiro Ikegami, Hisao Tajiri] Background: A valid biomarker for predicting the presence of gastric cancer may contribute to reducing deaths from this disease. Although pepsinogen (PG) testing has been introduced as a predictor, its predictive power is not satisfactory. We examined whether serum trefoil factor (TFF) could be a non-endoscopic predictor of the presence of gastric cancer. Methods: Gastric cancer patients who underwent preoperative endoscopy were sequentially recruited. Individuals who underwent a thorough medical checkup were enrolled as non-cancer controls. Serum levels of TFF1, TFF2, TFF3, Helicobacter pylori antibody, PG I, and PG II were examined. Results: We studied 192 gastric cancer patients aged 64.3±9.7years and 1254 non-cancer controls aged 52.3±12.4years. In the age/gender-matched analysis (187 cases and 561 controls), significant relationships were demonstrated between gastric cancer presence and TFF3 (P<0.0001), the PGI/II ratio (P<0.0001), H. pylori antibody (P=0.001), TFF1 (P=0.012), and TFF2 (P=0.020). The area under the receiver-operating characteristic curve for predicting gastric cancer presence was comparably high for all factors (0.893) and for the combination of TFF3 and the PG test (0.883), but was significantly (P<0.0001) lower for the PG test alone (0.823). A positive PG test showed a sensitivity of 67% and specificity of 82%, whereas a combination of TFF3 and PG testing showed a sensitivity of 80% and specificity of 80% in predicting the presence of gastric cancer. Conclusion: The combination of serum TFF3 and PG testing might be a valid non-endoscopic biomarker for predicting the presence of gastric cancer. Springer, 2011 Gastric cancer nationallicence Biomarker nationallicence Trefoil factor nationallicence Pepsinogen nationallicence H. pylori nationallicence Kaise Mitsuru Department of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, 105-8470, Tokyo, Japan aut Miwa Jun Department of Gastroenterology, Toshiba General Hospital, Tokyo, Japan aut Tashiro Jun Department of Gastroenterology, Toshiba General Hospital, Tokyo, Japan aut Ohmoto Yasukazu Institute of Biomedical Innovation, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan aut Morimoto Shingo Health Medical Center, Nomura Hospital, Tokyo, Japan aut Kato Masayuki Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan aut Urashima Mitsuyoshi Department of Clinical Research and Development, The Jikei University School of Medicine, Tokyo, Japan aut Ikegami Masahiro Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan aut Tajiri Hisao Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/6(2011-06-01), 736-745 0944-1174 46:6<736 2011 46 535 https://doi.org/10.1007/s00535-011-0396-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0396-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaise Mitsuru Department of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Miwa Jun Department of Gastroenterology, Toshiba General Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Tashiro Jun Department of Gastroenterology, Toshiba General Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohmoto Yasukazu Institute of Biomedical Innovation, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan aut NATIONALLICENCE 700 1- Morimoto Shingo Health Medical Center, Nomura Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Kato Masayuki Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Urashima Mitsuyoshi Department of Clinical Research and Development, The Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Ikegami Masahiro Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Tajiri Hisao Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/6(2011-06-01), 736-745 0944-1174 46:6<736 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer