caa a22 4500 445887885 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00535-011-0393-y doi (NATIONALLICENCE)springer-10.1007/s00535-011-0393-y Factors predictive of relapse and spontaneous remission of autoimmune pancreatitis patients treated/not treated with corticosteroids [Elektronische Daten] [Kensuke Kubota, Seitaro Watanabe, Takashi Uchiyama, Shingo Kato, Yusuke Sekino, Kaori Suzuki, Hironori Mawatari, Hiroshi Iida, Hiroki Endo, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Satoru Saito, Kazuya Sugimori, Kantaro Hisatomi, Nobuyuki Matsuhashi, Hirotaka Sato, Emiko Tanida, Takashi Sakaguchi, Nobutaka Fujisawa, Atsushi Nakajima] Background: Relapse and spontaneous remission (SR) are characteristic features of autoimmune pancreatitis (AIP). Aim and methods: We conducted a study to determine if the predictive factors might be potentially related to the relapse in 70 consecutive AIP patients. Regarding SR, we studied the data of patients without corticosteroid treatment (CST). Results: CST was administered to 60% (42/70) of the patients; however, relapse was noted in 45.2% (19/42) of these patients. In 95% (18/19) of the AIP patients developing relapse, the relapse occurred within 3years. The relapse rate was 80% (12/15) in the AIP patients administered CST for less than 12months and 25.9% (7/27) in those administered CST for over 12months (p<0.01). The results of univariate analysis revealed significant association of relapse with the presence of jaundice, IgG4 seropositivity, presence of diffuse pancreas swelling, duodenal papillitis (DP), history of initial CST, and history of supportive treatment (p<0.05), whereas multivariate analysis revealed that IgG4 seropositivity (OR 10.506, p=0.0422) and the presence of jaundice (OR 6.945, p=0.0174) are significant independent factors predictive of relapse in AIP patients. SR was recognized in 65.0% (13/20) of AIP patients without CST.The results of univariate analysis revealed that SR was associated with IgG4 seropositivity (p<0.05), and multivariate analysis identified IgG4 seropositivity (OR 0.032, p=0.0092) as a significant independent factor predictive of SR in these cases. Conclusion: AIP patients with IgG4 seropositivity and jaundice are at a higher risk of relapse and they could therefore be candidates for over 3years of maintenance CST. AIP patients with IgG4 seronegativity have a high likelihood of SR. Springer, 2011 AIP nationallicence Relapse nationallicence Spontaneous remission nationallicence Kubota Kensuke Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Watanabe Seitaro Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Uchiyama Takashi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Kato Shingo Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Sekino Yusuke Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Suzuki Kaori Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Mawatari Hironori Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Iida Hiroshi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Endo Hiroki Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Fujita Koji Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Yoneda Masato Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Takahashi Hirokazu Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Kirikoshi Hiroyuki Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Kobayashi Noritoshi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Saito Satoru Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Sugimori Kazuya Division of Gastroenterology, Urafune Hospital, Yokohama City University, Yokohama, Japan aut Hisatomi Kantaro Division of Gastroenterology, Kanto Medical Center, Shinagawa, Japan aut Matsuhashi Nobuyuki Division of Gastroenterology, Kanto Medical Center, Shinagawa, Japan aut Sato Hirotaka Division of Gastroenterology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan aut Tanida Emiko Division of Gastroenterology, Machida Metropolitan Hospital, Machida, Japan aut Sakaguchi Takashi Division of Gastroenterology, Hiratsuka Metropolitan Hospital, Hiratsuka, Japan aut Fujisawa Nobutaka Division of Gastroenterology, Tokyo Hiroo Metropolitan Hospital, Shibuya, Japan aut Nakajima Atsushi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut Journal of Gastroenterology Springer Japan 46/6(2011-06-01), 834-842 0944-1174 46:6<834 2011 46 535 https://doi.org/10.1007/s00535-011-0393-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0393-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kubota Kensuke Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Watanabe Seitaro Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Uchiyama Takashi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Kato Shingo Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Sekino Yusuke Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Suzuki Kaori Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Mawatari Hironori Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Iida Hiroshi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Endo Hiroki Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Fujita Koji Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Yoneda Masato Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Takahashi Hirokazu Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Kirikoshi Hiroyuki Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Kobayashi Noritoshi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Saito Satoru Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Sugimori Kazuya Division of Gastroenterology, Urafune Hospital, Yokohama City University, Yokohama, Japan aut NATIONALLICENCE 700 1- Hisatomi Kantaro Division of Gastroenterology, Kanto Medical Center, Shinagawa, Japan aut NATIONALLICENCE 700 1- Matsuhashi Nobuyuki Division of Gastroenterology, Kanto Medical Center, Shinagawa, Japan aut NATIONALLICENCE 700 1- Sato Hirotaka Division of Gastroenterology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Tanida Emiko Division of Gastroenterology, Machida Metropolitan Hospital, Machida, Japan aut NATIONALLICENCE 700 1- Sakaguchi Takashi Division of Gastroenterology, Hiratsuka Metropolitan Hospital, Hiratsuka, Japan aut NATIONALLICENCE 700 1- Fujisawa Nobutaka Division of Gastroenterology, Tokyo Hiroo Metropolitan Hospital, Shibuya, Japan aut NATIONALLICENCE 700 1- Nakajima Atsushi Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, 236-0004, Yokohama, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/6(2011-06-01), 834-842 0944-1174 46:6<834 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer