caa a22 4500 445887915 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00535-011-0378-x doi (NATIONALLICENCE)springer-10.1007/s00535-011-0378-x Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study [Elektronische Daten] [Takumi Kawaguchi, Naoto Shiba, Takashi Maeda, Toru Matsugaki, Yoshio Takano, Minoru Itou, Masahiro Sakata, Eitaro Taniguchi, Kensei Nagata, Michio Sata] Background: Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). "Hybrid training”, a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The aim of this study was to investigate the therapeutic efficacy of hybrid training in patients with NAFLD. Methods: Thirty-five patients with NAFLD who were resistant to lifestyle counseling were assigned to a hybrid-training group (n=12) or a control group (n=23). In the hybrid-training group, quadriceps and hamstrings were contracted voluntarily or electrically for 19min twice a week. In the control group, patients received lifestyle counseling. The therapeutic efficacy of the hybrid training was evaluated after 12weeks of the intervention. Results: Serum alanine aminotransferase (ALT) levels and hepatic steatosis grade were significantly decreased in the hybrid-training group compared to that of the control group (−14.1±5.8 vs. 3.5±5.4IU/mL; P<0.05, −0.67±0.19 vs. 0.09±0.06 grade; P<0.01, respectively). No significant changes were seen between the two groups in skeletal muscle mass. The decreases in homeostasis model assessment of insulin resistance (HOMA-IR) value and in serum IL-6 levels were significantly greater in the hybrid-training group than in the control group (−6.2±3.2 vs. 0.4±0.6; P<0.05, −3.1±1.1 vs. 1.1±0.5pg/mL; P<0.01, respectively). Conclusion: Hybrid training of voluntary and electrical muscle contractions improved hepatic steatosis and reduced insulin resistance and serum IL-6 levels in NAFLD patients who are resistant to lifestyle counseling. Springer, 2011 Exercise nationallicence Nonalcoholic fatty liver disease nationallicence Insulin resistance nationallicence Myokine nationallicence NAFLD : Non-alcoholic fatty liver disease nationallicence IL : Interleukin nationallicence ALT : Alanine aminotransferase nationallicence BIA : Bioelectrical impedance analyzer nationallicence BMI : Body mass index nationallicence CV : Coefficient of variation nationallicence AST : Aspartate aminotransferase nationallicence LDH : Lactate dehydrogenase nationallicence ALP : Alkaline phosphatase nationallicence GGT : Gamma-glutamyl transpeptidase nationallicence HDL : High-density lipoprotein nationallicence LDL : Low-density lipoprotein nationallicence BUN : Blood urea nitrogen nationallicence CK : Creatine kinase nationallicence HOMA-IR : Homeostasis model assessment of insulin resistance nationallicence HOMA-%B : Homeostasis model assessment of beta-cell function nationallicence EMS : Electrical muscle stimulation nationallicence GLUT : Glucose transporter nationallicence Kawaguchi Takumi Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Japan aut Shiba Naoto Division of Rehabilitation, Kurume University Hospital, Kurume, Japan aut Maeda Takashi Division of Rehabilitation, Kurume University Hospital, Kurume, Japan aut Matsugaki Toru Department of Orthopedic Surgery, Kurume University School of Medicine, 830-0011, Kurume, Japan aut Takano Yoshio Division of Rehabilitation, Kurume University Hospital, Kurume, Japan aut Itou Minoru Department of Medicine, Kurume University School of Medicine, Kurume, Japan aut Sakata Masahiro Department of Medicine, Kurume University School of Medicine, Kurume, Japan aut Taniguchi Eitaro Department of Medicine, Kurume University School of Medicine, Kurume, Japan aut Nagata Kensei Department of Orthopedic Surgery, Kurume University School of Medicine, 830-0011, Kurume, Japan aut Sata Michio Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Japan aut Journal of Gastroenterology Springer Japan 46/6(2011-06-01), 746-757 0944-1174 46:6<746 2011 46 535 https://doi.org/10.1007/s00535-011-0378-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0378-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawaguchi Takumi Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Japan aut NATIONALLICENCE 700 1- Shiba Naoto Division of Rehabilitation, Kurume University Hospital, Kurume, Japan aut NATIONALLICENCE 700 1- Maeda Takashi Division of Rehabilitation, Kurume University Hospital, Kurume, Japan aut NATIONALLICENCE 700 1- Matsugaki Toru Department of Orthopedic Surgery, Kurume University School of Medicine, 830-0011, Kurume, Japan aut NATIONALLICENCE 700 1- Takano Yoshio Division of Rehabilitation, Kurume University Hospital, Kurume, Japan aut NATIONALLICENCE 700 1- Itou Minoru Department of Medicine, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Sakata Masahiro Department of Medicine, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Taniguchi Eitaro Department of Medicine, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Nagata Kensei Department of Orthopedic Surgery, Kurume University School of Medicine, 830-0011, Kurume, Japan aut NATIONALLICENCE 700 1- Sata Michio Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/6(2011-06-01), 746-757 0944-1174 46:6<746 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer