caa a22 4500 44588794X CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0418-6 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0418-6 Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer [Elektronische Daten] [Masaaki Kobayashi, Manabu Takeuchi, Yoichi Ajioka, Satoru Hashimoto, Akito Sato, Rintaro Narisawa, Yutaka Aoyagi] Background: Several studies have described the surface glandular structure in differentiated early gastric cancer observed by narrow-band imaging with magnifying endoscopy (NBI-ME) in two main patterns, i.e., a papillary or granular structure in an intralobular loop pattern (ILL) and a pit structure in a fine network pattern (FNP). However, it is uncertain why the NBI-ME findings of differentiated-type carcinomas are divided into two main patterns. We investigated the significance of the mucin phenotype in the morphogenetic difference between ILL and FNP. Methods: We evaluated 120 intramucosal, well- or predominantly well-differentiated tubular adenocarcinomas. In each lesion, one area that showed the predominant pattern of microsurface structures and microvessels was selected and marked by electrocoagulation for a strict comparative study by NBI-ME and pathological investigation. NBI-ME findings were classified into three patterns: ILL, FNP, and intermediate. Mucin phenotypes were judged as gastric, intestinal, or gastrointestinal type by immunohistochemistry. Results: The mucin phenotype was gastric or gastrointestinal type in 24 (92.3%) of 26 ILL lesions. Intestinal phenotype was observed in 22 (84.6%) of 26 FNP lesions. The gastrointestinal phenotype was observed in 50 (73.5%) of 68 intermediate pattern lesions. The mucin phenotype and NBI-ME results were significantly correlated (P<0.001). Conclusions: The mucin phenotype of differentiated early gastric cancer might be involved in morphogenetic differences between the papillary and pit structures visualized by NBI-ME. Springer, 2011 Gastric phenotype nationallicence Intestinal phenotype nationallicence Intralobular loop pattern nationallicence Fine network pattern nationallicence Kobayashi Masaaki Department of Endoscopy, Niigata University Medical and Dental Hospital, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Japan aut Takeuchi Manabu Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut Ajioka Yoichi Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan aut Hashimoto Satoru Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut Sato Akito Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut Narisawa Rintaro Department of Endoscopy, Niigata University Medical and Dental Hospital, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Japan aut Aoyagi Yutaka Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1064-1070 0944-1174 46:9<1064 2011 46 535 https://doi.org/10.1007/s00535-011-0418-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0418-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobayashi Masaaki Department of Endoscopy, Niigata University Medical and Dental Hospital, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Takeuchi Manabu Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut NATIONALLICENCE 700 1- Ajioka Yoichi Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan aut NATIONALLICENCE 700 1- Hashimoto Satoru Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut NATIONALLICENCE 700 1- Sato Akito Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut NATIONALLICENCE 700 1- Narisawa Rintaro Department of Endoscopy, Niigata University Medical and Dental Hospital, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Aoyagi Yutaka Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1064-1070 0944-1174 46:9<1064 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer