caa a22 4500 445887958 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0421-y doi (NATIONALLICENCE)springer-10.1007/s00535-011-0421-y Present status of autoimmune hepatitis in Japan: a nationwide survey [Elektronische Daten] [Masanori Abe, Toshie Mashiba, Mikio Zeniya, Kazuhide Yamamoto, Morikazu Onji, Hirohito Tsubouchi] Background: A nationwide survey of autoimmune hepatitis (AIH) was conducted in Japan, and the clinical features of patients with AIH were analyzed. Methods: A total of 1,056 patients were enrolled through questionnaires sent to 153 hospitals and clinics with hepatology specialists. Results: The clinical features of Japanese AIH were as follows: (1) most patients were middle-aged women, with ages peaking in the 60s; (2) serum immunoglobulin G (IgG) levels were high, but more than 30% of the patients had serum IgG levels less than 2,000mg/dl; the cutoff level of IgG to distinguish between patients with AIH and those with chronic hepatitis resulting from hepatitis virus was approximately 2,000mg/dl; (3) autoantibodies, particularly the antinuclear antibody, were frequently present; (4) most patients showed histological features of chronic hepatitis or liver cirrhosis, but 10.9% of the patients showed histological features of acute hepatitis; (5) approximately 75% of the patients were treated with corticosteroids and showed a favorable response to treatment, whereas ursodeoxycholic acid was administered to 60% of the patients. Conclusions: The clinical features of patients with AIH in Japan were clarified. The mean age at diagnosis was higher than that in previous studies. In addition, the number of patients with AIH having the histological features of acute hepatitis increased. Diagnosis of AIH does not preclude the presence of acute hepatitis and/or serum IgG levels less than 2,000mg/dl. Springer, 2011 Autoimmune hepatitis nationallicence Clinical features nationallicence Nationwide survey nationallicence Immunoglobulin G nationallicence Acute hepatitis nationallicence Abe Masanori Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Mashiba Toshie Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Zeniya Mikio Department of Gastroenterology, Jikei University Graduate School of Medicine, Tokyo, Japan aut Yamamoto Kazuhide Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut Onji Morikazu Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Tsubouchi Hirohito Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1136-1141 0944-1174 46:9<1136 2011 46 535 https://doi.org/10.1007/s00535-011-0421-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0421-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abe Masanori Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Mashiba Toshie Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Zeniya Mikio Department of Gastroenterology, Jikei University Graduate School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamamoto Kazuhide Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut NATIONALLICENCE 700 1- Onji Morikazu Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Tsubouchi Hirohito Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1136-1141 0944-1174 46:9<1136 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer