caa a22 4500 445887966 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0425-7 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0425-7 Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease [Elektronische Daten] [Jun Miyoshi, Tomoharu Yajima, Susumu Okamoto, Katsuyoshi Matsuoka, Nagamu Inoue, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Atsushi Nakazawa, Takanori Kanai, Haruhiko Ogata, Yasushi Iwao, Makio Mukai, Toshifumi Hibi] Background: Host-intestinal microbial interaction plays an important role in the pathogenesis of inflammatory bowel diseases (IBDs). The surface molecules of the intestinal epithelium act as receptors for bacterial adhesion and regulate the intestinal bacteria. Some known receptors are the mucosal blood type antigens, which are regulated by the fucosyltransferase2 (FUT2) gene, and individuals who express these antigens in the gastrointestinal tract are called secretors. Recent research has revealed that the FUT2 gene is associated with Crohn's disease (CD) in western populations. Methods: To clarify the contribution of mucosal blood type antigens in IBD, we determined the incidence of five previously reported single-nucleotide polymorphisms of the FUT2 gene in Japanese patients. We also used immunohistochemistry to investigate the antigen expression in mucosal specimens from IBD patients and animal models. Results: Genetic analysis revealed that all of the patients with colonic CD were secretors, whereas the incidence of secretors was 80, 80, 67, and 80%, respectively, for the control, ileocolonic CD, ileal CD, and ulcerative colitis groups (P=0.036). Abnormal expression of blood type antigens was observed only in colonic CD. Interleukin-10−/− mice, but not dextran sulfate sodium colitis mice, had enhanced colonic expression of blood type antigens, and the expression of these antigens preceded the development of colitis in the interleukin-10−/− mice. Conclusions: FUT2 secretor status was associated with colonic-type CD. This finding, taken together with the immunohistochemistry data, suggests that the abnormal expression of blood type antigens in the colon may be a unique and essential factor for colonic CD. Springer, 2011 Colonic Crohn's disease nationallicence FUT2 nationallicence Blood type antigen nationallicence Miyoshi Jun Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Yajima Tomoharu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Okamoto Susumu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Matsuoka Katsuyoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Inoue Nagamu Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Hisamatsu Tadakazu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Shimamura Katsuyoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Nakazawa Atsushi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Kanai Takanori Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Ogata Haruhiko Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Iwao Yasushi Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Mukai Makio Division of Diagnostic Pathology, School of Medicine, Keio University, Tokyo, Japan aut Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1056-1063 0944-1174 46:9<1056 2011 46 535 https://doi.org/10.1007/s00535-011-0425-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0425-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyoshi Jun Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Yajima Tomoharu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Okamoto Susumu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsuoka Katsuyoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Inoue Nagamu Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Hisamatsu Tadakazu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Shimamura Katsuyoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakazawa Atsushi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Kanai Takanori Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogata Haruhiko Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwao Yasushi Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Mukai Makio Division of Diagnostic Pathology, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1056-1063 0944-1174 46:9<1056 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer