caa a22 4500 445887974 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0435-5 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0435-5 Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients [Elektronische Daten] [Hirofumi Fujishiro, Yuji Amano, Yoshinori Kushiyama, Shunji Ishihara, Yoshikazu Kinoshita] Background: The prevalence of eosinophilic esophagitis (EE) is increasing rapidly in Western countries. Several case series of EE have also been reported in Japan. However, the prevalence of EE in Japanese patients as investigated by upper gastrointestinal endoscopy is unknown. Therefore, we carried out a prospective multicenter study to address this issue. Methods: From July to December 2010, 23,346 patients who had undergone routine upper gastrointestinal endoscopy in 17 institutions were enrolled. In patients with symptoms suggesting EE, such as dysphasia, food impaction, and heartburn, and/or in patients in whom endoscopic findings suggested pathology, esophageal biopsy samples were collected, and the numbers of eosinophils in the squamous epithelium were counted. Results: During the study period of 6months, 4 patients were endoscopically and histologically diagnosed with EE. The prevalence of EE was calculated to be 17.1/100,000. Conclusion: The prevalence of EE in Japanese patients by upper gastrointestinal endoscopy has now been documented. Springer, 2011 Eosinophilic esophagitis nationallicence Prevalence nationallicence Japanese population nationallicence Fujishiro Hirofumi Division of Endoscopy, Shimane Prefectural Central Hospital, Izumo, Japan aut Amano Yuji Division of Endoscopy, Shimane University Hospital, 89-1 Enya-cho, 693-8501, Izumo, Shimane, Japan aut Kushiyama Yoshinori Division of Gastroenterology, Matsue Red Cross Hospital, Matsue, Japan aut Ishihara Shunji Second Department of Internal Medicine, Shimane University, Faculty of Medicine, Izumo, Japan aut Kinoshita Yoshikazu Second Department of Internal Medicine, Shimane University, Faculty of Medicine, Izumo, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1142-1144 0944-1174 46:9<1142 2011 46 535 https://doi.org/10.1007/s00535-011-0435-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0435-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujishiro Hirofumi Division of Endoscopy, Shimane Prefectural Central Hospital, Izumo, Japan aut NATIONALLICENCE 700 1- Amano Yuji Division of Endoscopy, Shimane University Hospital, 89-1 Enya-cho, 693-8501, Izumo, Shimane, Japan aut NATIONALLICENCE 700 1- Kushiyama Yoshinori Division of Gastroenterology, Matsue Red Cross Hospital, Matsue, Japan aut NATIONALLICENCE 700 1- Ishihara Shunji Second Department of Internal Medicine, Shimane University, Faculty of Medicine, Izumo, Japan aut NATIONALLICENCE 700 1- Kinoshita Yoshikazu Second Department of Internal Medicine, Shimane University, Faculty of Medicine, Izumo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1142-1144 0944-1174 46:9<1142 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer