caa a22 4500 445888008 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0423-9 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0423-9 Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans [Elektronische Daten] [Yuuichi Aizawa, Joe Morishita, Michiko Kano, Takayuki Mori, Shin-Ichi Izumi, Kenichiro Tsutsui, Toshio Iijima, Motoyori Kanazawa, Shin Fukudo] Background: A previous brain imaging study demonstrated activation of the right dorsolateral prefrontal cortex (DLPFC) during visceral nociception, and this activation was associated with anxiety. We hypothesized that functional modulation of the right DLPFC by repetitive transcranial magnetic stimulation (rTMS) can reveal the actual role of right DLPFC in brain-gut interactions in humans. Methods: Subjects were 11 healthy males aged 23.5±1.4 (mean±SE) years. Viscerosensory evoked potential (VEP) with sham (0mA) or actual (30mA) electrical stimulation (ES) of the rectum was taken after sham, low frequency rTMS at 0.1Hz, and high frequency rTMS at 10Hz to the right DLPFC. Rectal tone was measured with a rectal barostat. Visceral perception and emotion were analyzed using an ordinate scale, rectal barostat, and VEP. Key results: Low frequency rTMS significantly reduced anxiety evoked by ES at 30mA (p<0.05). High frequency rTMS-30mA ES significantly produced more phasic volume events than sham rTMS-30mA ES (p<0.05). Conclusions and inferences: We successfully modulated the gastrointestinal function of healthy individuals through rTMS to the right DLPFC. Thus, rTMS to the DLPFC appears to modulate the affective, but not direct, component of visceral perception and motility of the rectum. Springer, 2011 Irritable bowel syndrome (IBS) nationallicence Repetitive transcranial magnetic stimulation (rTMS) nationallicence Dorsolateral prefrontal cortex (DLPFC) nationallicence Viscerosensory evoked potential (VEP) nationallicence Visceral perception nationallicence Electroencephalogram (EEG) nationallicence IBS : Irritable bowel syndrome nationallicence rTMS : Repetitive transcranial magnetic stimulation nationallicence DLPFC : Dorsolateral prefrontal cortex nationallicence VEP : Viscerosensory evoked potential nationallicence EEG : Electroencephalogram nationallicence Aizawa Yuuichi Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut Morishita Joe Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut Kano Michiko Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut Mori Takayuki Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan aut Izumi Shin-Ichi Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan aut Tsutsui Kenichiro Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan aut Iijima Toshio Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan aut Kanazawa Motoyori Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut Fukudo Shin Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1071-1080 0944-1174 46:9<1071 2011 46 535 https://doi.org/10.1007/s00535-011-0423-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0423-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aizawa Yuuichi Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Morishita Joe Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Kano Michiko Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Mori Takayuki Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Izumi Shin-Ichi Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Tsutsui Kenichiro Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Iijima Toshio Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Kanazawa Motoyori Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Fukudo Shin Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, 980-8575, Sendai, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1071-1080 0944-1174 46:9<1071 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer