caa a22 4500 445888032 CHVBK 20180317145605.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0420-z doi (NATIONALLICENCE)springer-10.1007/s00535-011-0420-z Novel classification of acute liver failure through clustering using a self-organizing map: usefulness for prediction of the outcome [Elektronische Daten] [Nobuaki Nakayama, Makoto Oketani, Yoshihiro Kawamura, Mie Inao, Sumiko Nagoshi, Kenji Fujiwara, Hirohito Tsubouchi, Satoshi Mochida] Background: Patients with acute liver failure are classified according to the interval between the onset of hepatitis symptoms and the development of hepatic encephalopathy. We examined the validity of such classifications. Methods: The subjects were 1,022 patients enrolled in a nationwide survey in Japan. The intervals between the onset of the hepatitis symptoms and the development of encephalopathy were 10days or less in 472 patients (group-A), between 11 and 56days in 468 patients (group-B), and longer than 56days in 82 patients (group-C). Data on a total of 104 items collected from the patients were subjected to clustering using a self-organizing map. Results: The patients were classified into three clusters. The first cluster consisted of 411 patients (group-A: 57%, group-B: 39%, group-C: 4%). Their incidence of complications was low; 34% underwent liver transplantation (LT), and their survival rate was 90%, while 94% of those treated without transplant were rescued. The second cluster consisted of 320 patients (21, 65, and 14% groups A, B, and C, respectively), who showed a high incidence of complications; the survival rate was 7% in the patients treated conservatively without LT. Sixteen percent underwent LT and survival rate of these patients was 52%. There was a third cluster, of 291 patients (59, 34, and 7% groups A, B, and C, respectively). Without LT, 81% of the patients died. Seven percent were treated by LT and their survival rate was 60%. Conclusions: Clustering revealed that patients with acute liver failure could be classified into three clusters independent of the interval between the onset of disease symptoms and the development of encephalopathy. This technique may be useful, since the outcomes of the patients differed markedly among the clusters. Springer, 2011 Hepatic encephalopathy nationallicence Fulminant hepatitis nationallicence Data-mining nationallicence Artificial neural network nationallicence Liver transplantation nationallicence LOHF : Late-onset hepatic failure nationallicence LT : Liver transplantation nationallicence DIC : Disseminated intravascular coagulation nationallicence SOM : Self-organizing map nationallicence HBV : Hepatitis B virus nationallicence HAV : Hepatitis A virus nationallicence Nakayama Nobuaki Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut Oketani Makoto Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut Kawamura Yoshihiro Life Sciences Solutions, IBM Japan, Tokyo, Japan aut Inao Mie Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut Nagoshi Sumiko Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut Fujiwara Kenji Yokohama Rosai Hospital for Labor Welfare Corporation, Yokohama, Japan aut Tsubouchi Hirohito Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut Mochida Satoshi Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1127-1135 0944-1174 46:9<1127 2011 46 535 https://doi.org/10.1007/s00535-011-0420-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0420-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakayama Nobuaki Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut NATIONALLICENCE 700 1- Oketani Makoto Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut NATIONALLICENCE 700 1- Kawamura Yoshihiro Life Sciences Solutions, IBM Japan, Tokyo, Japan aut NATIONALLICENCE 700 1- Inao Mie Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut NATIONALLICENCE 700 1- Nagoshi Sumiko Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut NATIONALLICENCE 700 1- Fujiwara Kenji Yokohama Rosai Hospital for Labor Welfare Corporation, Yokohama, Japan aut NATIONALLICENCE 700 1- Tsubouchi Hirohito Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut NATIONALLICENCE 700 1- Mochida Satoshi Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, 350-0495, Saitama, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1127-1135 0944-1174 46:9<1127 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer