caa a22 4500 445888040 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0412-z doi (NATIONALLICENCE)springer-10.1007/s00535-011-0412-z Pretreatment prediction of anemia progression by pegylated interferon alpha-2b plus ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysis [Elektronische Daten] [Naoki Hiramatsu, Masayuki Kurosaki, Naoya Sakamoto, Manabu Iwasaki, Minoru Sakamoto, Yoshiyuki Suzuki, Fuminaka Sugauchi, Akihiro Tamori, Sei Kakinnuma, Kentaro Matsuura, Namiki Izumi] Background: This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy. Methods: Data were collected from 1081 genotype 1b chronic hepatitis C patients who were treated at 6 hospitals in Japan. These patients were randomly assigned to a model-building group (n=691) or an internal validation group (n=390). Factors predictive of severe anemia (hemoglobin, Hb<8.5g/dl) were explored using data-mining analysis. Results: Hb values at baseline, creatinine clearance (Ccr), and an Hb concentration decline by 2g/dl at week 2 were used to build a decision-tree model, in which the patients were divided into 5 subgroups based on variable rates of severe anemia ranging from 0.4 to 11.8%. The reproducibility of the model was confirmed by the internal validation group (r 2=0.96). The probability of severe anemia was high in patients whose Hb value was <14g/dl before treatment (6.5%), especially (a) in those whose Ccr was <80ml/min (11.8%) and (b) those whose Ccr was ≥80ml/min but whose Hb concentration decline at week 2 was ≥2g/dl (11.5%). The probability of severe anemia was low in the other patients (0.4-2.5%). Conclusions: The decision-tree model that included Hb values at baseline, Ccr, and an Hb concentration decline by 2g/dl at week 2 was useful for predicting the probability of severe anemia, and has the potential to support clinical decisions regarding early dose reduction of ribavirin. Springer, 2011 Data mining nationallicence Decision tree nationallicence Severe anemia nationallicence Chronic hepatitis C nationallicence Pegylated interferon nationallicence Ribavirin nationallicence Hb : Hemoglobin nationallicence PEG-IFN : Pegylated interferon nationallicence Ccr : Creatinine clearance nationallicence SVR : Sustained virological response nationallicence AFP : Alpha-fetoprotein nationallicence Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan aut Kurosaki Masayuki Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, 180-8610, Musashino, Tokyo, Japan aut Sakamoto Naoya Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan aut Iwasaki Manabu Department of Computer and Information Science, Seikei University, Tokyo, Japan aut Sakamoto Minoru First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan aut Suzuki Yoshiyuki Department of Hepatology, Toranomon Hospital, Tokyo, Japan aut Sugauchi Fuminaka Department of Gastroenterology, Nagoya Koseiin Medical Welfare Center, Nagoya, Japan aut Tamori Akihiro Department of Hepatology, Osaka City University Medical School, Osaka, Japan aut Kakinnuma Sei Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan aut Matsuura Kentaro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut Izumi Namiki Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, 180-8610, Musashino, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1111-1119 0944-1174 46:9<1111 2011 46 535 https://doi.org/10.1007/s00535-011-0412-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0412-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Kurosaki Masayuki Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, 180-8610, Musashino, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Naoya Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwasaki Manabu Department of Computer and Information Science, Seikei University, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Minoru First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan aut NATIONALLICENCE 700 1- Suzuki Yoshiyuki Department of Hepatology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugauchi Fuminaka Department of Gastroenterology, Nagoya Koseiin Medical Welfare Center, Nagoya, Japan aut NATIONALLICENCE 700 1- Tamori Akihiro Department of Hepatology, Osaka City University Medical School, Osaka, Japan aut NATIONALLICENCE 700 1- Kakinnuma Sei Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsuura Kentaro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut NATIONALLICENCE 700 1- Izumi Namiki Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, 180-8610, Musashino, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1111-1119 0944-1174 46:9<1111 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer