caa a22 4500 445888059 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00535-011-0424-8 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0424-8 Gastrointestinal stem cells in self-renewal and cancer [Elektronische Daten] [S. Lin, Nick Barker] The gastrointestinal epithelium is a unique model for the study of mammalian stem cells. Not only does it have a highly stereotypical organization, its remarkable rate of self-renewal provides a daily readout of stem cell activity. The past decade has seen a major investment in developing technologies dedicated to revealing the identity of the long-elusive gastrointestinal stem cells. An array of purported stem cell biomarkers is now available for the mouse, including surface-expressed proteins that hold great promise as antibody targets for use in isolating human stem cells. Here we critically appraise the validity of these biomarkers and discuss their likely impact on our understanding of stem cell roles in self-renewal and cancer in the gastrointestinal tract. Springer, 2011 Intestine nationallicence Stomach nationallicence Cancer nationallicence Stem cell nationallicence Self-renewal nationallicence Lin S. Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore aut Barker Nick Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore aut Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1039-1055 0944-1174 46:9<1039 2011 46 535 https://doi.org/10.1007/s00535-011-0424-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0424-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin S. Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore aut NATIONALLICENCE 700 1- Barker Nick Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/9(2011-09-01), 1039-1055 0944-1174 46:9<1039 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer