caa a22 4500 445888075 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00535-011-0410-1 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0410-1 Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study [Elektronische Daten] [Hiroki Endo, Takuma Higurashi, Kunihiro Hosono, Eiji Sakai, Yusuke Sekino, Hiroshi Iida, Yasunari Sakamoto, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Chikako Tokoro, Masahiko Inamori, Yasunobu Abe, Atsushi Nakajima] Background: Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. Methods: Thirty-five patients who took low-dose enteric-coated aspirin 100mg daily (for more than 3months) plus omeprazole 20mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with Lactobacillus casei for 3months (L. casei group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment. Results: Twenty-five patients, including 13 in the L. casei group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the L. casei group as compared with the results in the control group (P=0.039). The change from the baseline in the median number of mucosal breaks in the L. casei group was −2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the L. casei group was −228 compared with −4 in the control group (P=0.026). Conclusions: Co-administration of L. casei is effective for the treatment of aspirin-associated small bowel injury. Springer, 2011 Low-dose aspirin nationallicence Capsule endoscopy nationallicence Small bowel nationallicence Probiotics nationallicence Endo Hiroki Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Higurashi Takuma Department of Gastroenterology, Yokohama Rosai Hospital, 3211 Kozukue, Kohoku-ku, Yokohama, Japan aut Hosono Kunihiro Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Sakai Eiji Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Sekino Yusuke Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Iida Hiroshi Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Sakamoto Yasunari Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Koide Tomoko Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Takahashi Hirokazu Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Yoneda Masato Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Tokoro Chikako Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Inamori Masahiko Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Abe Yasunobu Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Nakajima Atsushi Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 894-905 0944-1174 46:7<894 2011 46 535 https://doi.org/10.1007/s00535-011-0410-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0410-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Endo Hiroki Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Higurashi Takuma Department of Gastroenterology, Yokohama Rosai Hospital, 3211 Kozukue, Kohoku-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Hosono Kunihiro Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Sakai Eiji Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Sekino Yusuke Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Iida Hiroshi Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Sakamoto Yasunari Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Koide Tomoko Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Takahashi Hirokazu Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Yoneda Masato Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Tokoro Chikako Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Inamori Masahiko Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Abe Yasunobu Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 700 1- Nakajima Atsushi Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 894-905 0944-1174 46:7<894 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 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