caa a22 4500 445888083 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00535-011-0403-0 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0403-0 The efficacy of extended treatment with pegylated interferon plus ribavirin in patients with HCV genotype 1 and slow virologic response in Japan [Elektronische Daten] [Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Kazuho Imanaka, Akira Yamada, Masahide Oshita, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Toshihiko Nagase, Yoshiaki Inui, Taizo Hijioka, Shinji Tamura, Harumasa Yoshihara, Eijiro Hayashi, Yasuharu Imai, Michio Kato, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Hisashi Ishida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi] Background: Which patients with hepatitis C virus (HCV) genotype 1 can benefit from extended treatment with pegylated interferon (Peg-IFN) plus ribavirin is unknown, although the overall sustained virologic response (SVR) rate has been shown to improve in patients with a late virologic response (LVR), defined as detectable serum HCV RNA at week 12 and undetectable at week 24. Methods: Among 1163 chronic hepatitis C patients with genotype 1 treated with Peg-IFN plus ribavirin combination therapy, 213 patients with an LVR were examined in this study. In addition, we selected 81 patients of matched sex and age from each of the 48- and 72-week treatment groups, using the propensity score, to compare the efficacy of the two treatment durations. Results: With 72-week treatment, the timing of HCV RNA disappearance and the hemoglobin level at baseline showed a strong correlation with the SVR on multivariate analysis. Earlier HCV RNA disappearance was associated with a better SVR rate, regardless of the ribavirin dose (HCV RNA disappearance at week 16, 74%; at week 20, 52%; and at week 24, 31%, p=0.01). The SVR rate with 72-week treatment was higher than that with 48-week treatment, irrespective of age, sex, or the platelet value, and, especially in aged patients (≥65years old), the SVR rate increased markedly with 72-week treatment (48weeks, 25% vs. 72weeks, 56%; p<0.05). Conclusions: An earlier response predicts a higher SVR rate in patients with an LVR given 72-week treatment. Extended treatment with Peg-IFN plus ribavirin for patients with an LVR improved the treatment efficacy, even for aged patients. Springer, 2011 Chronic hepatitis C nationallicence Pegylated interferon and ribavirin combination therapy nationallicence Extended treatment nationallicence Aged patients nationallicence Oze Tsugiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yakushijin Takayuki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Mochizuki Kiyoshi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Imanaka Kazuho Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Yamada Akira Sumitomo Hospital, Osaka, Japan aut Oshita Masahide Osaka Police Hospital, Osaka, Japan aut Kaneko Akira NTT West Osaka Hospital, Osaka, Japan aut Hagiwara Hideki Kansai Rousai Hospital, Amagasaki, Japan aut Mita Eiji National Hospital Organization Osaka National Hospital, Osaka, Japan aut Ito Toshifumi Osaka Koseinenkin Hospital, Osaka, Japan aut Nagase Toshihiko Suita Municipal Hospital, Suita, Japan aut Inui Yoshiaki Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan aut Hijioka Taizo National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan aut Tamura Shinji Minoh City Hospital, Minoh, Japan aut Yoshihara Harumasa Osaka Rousai Hospital, Sakai, Japan aut Hayashi Eijiro Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami, Japan aut Imai Yasuharu Ikeda Municipal Hospital, Ikeda, Japan aut Kato Michio National Hospital Organization Minami Wakayama Medical Center, Tanabe, Japan aut Hosui Atsushi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Miyagi Takuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Ishida Hisashi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Tatsumi Tomohide Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kanto Tatsuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kasahara Akinori Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Hayashi Norio Kansai Rousai Hospital, Amagasaki, Japan aut Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 944-952 0944-1174 46:7<944 2011 46 535 https://doi.org/10.1007/s00535-011-0403-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0403-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oze Tsugiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yakushijin Takayuki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Mochizuki Kiyoshi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Imanaka Kazuho Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Yamada Akira Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Oshita Masahide Osaka Police Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Kaneko Akira NTT West Osaka Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Hagiwara Hideki Kansai Rousai Hospital, Amagasaki, Japan aut NATIONALLICENCE 700 1- Mita Eiji National Hospital Organization Osaka National Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Ito Toshifumi Osaka Koseinenkin Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Nagase Toshihiko Suita Municipal Hospital, Suita, Japan aut NATIONALLICENCE 700 1- Inui Yoshiaki Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Hijioka Taizo National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan aut NATIONALLICENCE 700 1- Tamura Shinji Minoh City Hospital, Minoh, Japan aut NATIONALLICENCE 700 1- Yoshihara Harumasa Osaka Rousai Hospital, Sakai, Japan aut NATIONALLICENCE 700 1- Hayashi Eijiro Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami, Japan aut NATIONALLICENCE 700 1- Imai Yasuharu Ikeda Municipal Hospital, Ikeda, Japan aut NATIONALLICENCE 700 1- Kato Michio National Hospital Organization Minami Wakayama Medical Center, Tanabe, Japan aut NATIONALLICENCE 700 1- Hosui Atsushi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Miyagi Takuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ishida Hisashi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Tatsumi Tomohide Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kanto Tatsuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kasahara Akinori Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hayashi Norio Kansai Rousai Hospital, Amagasaki, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 944-952 0944-1174 46:7<944 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer