caa a22 4500 445888113 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00535-011-0402-1 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0402-1 Treatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: a randomized controlled trial [Elektronische Daten] [Victoria Tan, Wai Wong, Ting Cheung, Kam Lai, Ivan Hung, Pierre Chan, Roberta Pang, Benjamin Wong] Background: Evidence suggests that rates of gastroesophageal reflux disease are increasing in the Asia-Pacific region, where patients tend to have predominantly non-erosive reflux disease as opposed to erosive (reflux) esophagitis. At present, data for the responsiveness of non-erosive reflux disease to proton pump inhibition are scant. We aimed to study esomeprazole for the treatment of non-erosive reflux disease in Chinese patients. Methods: Patients with a clinical diagnosis of gastroesophageal reflux, and a locally validated reflux index, the Chinese GerdQ, of equal to or greater than 12 were recruited and randomized to receive esomeprazole 20mg daily or placebo for 8weeks. Reflux index scores, quality of life (SF-36), and the hospital anxiety and depression (HAD) scale and symptom relief were evaluated before, during, and after treatment. Results: A total of 175 patients were randomized. Patients in the esomeprazole group (n=85) demonstrated statistically significant reductions in their GerdQ index, from 19.45 to 15.37 and to 14.32 (p=0.013, p=0.005) at weeks 4 and 8, respectively. Compared to placebo at week 8, 57.1% of patients on esomeprazole found that their symptoms had resolved or were acceptable compared with 37.2% in the placebo group (p=0.001). There were no statistically significant differences in overall quality-of-life measures or the HAD scale related to treatment. Conclusions: This study suggests that esomeprazole is efficacious in treating Chinese patients with non-erosive reflux disease. Springer, 2011 GERD nationallicence Proton pump inhibitor nationallicence Clinical trial nationallicence Tan Victoria Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Wong Wai Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Cheung Ting Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Lai Kam Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Hung Ivan Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Chan Pierre Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Pang Roberta Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Wong Benjamin Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 906-912 0944-1174 46:7<906 2011 46 535 https://doi.org/10.1007/s00535-011-0402-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0402-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tan Victoria Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Wong Wai Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Cheung Ting Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Lai Kam Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Hung Ivan Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Chan Pierre Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Pang Roberta Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Wong Benjamin Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 906-912 0944-1174 46:7<906 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer