caa a22 4500 44588813X CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00535-011-0406-x doi (NATIONALLICENCE)springer-10.1007/s00535-011-0406-x Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system [Elektronische Daten] [Toru Beppu, Hiromitsu Hayashi, Hirohisa Okabe, Toshiro Masuda, Kosuke Mima, Ryu Otao, Akira Chikamoto, Koichi Doi, Takatoshi Ishiko, Hiroshi Takamori, Morikatsu Yoshida, Shinya Shiraishi, Yasuyuki Yamashita, Hideo Baba] Background: We developed a new combined 99mTc-galactosyl human serum albumin (GSA) scintigraphy single-photon emission computed tomography (SPECT)/CT system to evaluate the changes in functional liver volume with portal vein embolization (PVE). Methods: We performed a prospective analysis of 25 patients treated with right PVE, and evaluated their functional liver volume perioperatively with a 99mTc-GSA scintigraphy SPECT-CT fusion system. The percentage of the non-tumorous remnant liver volume (%LV) and the percentage of functional remnant liver volume (%FLV) were estimated by using the following calculations: (future remnant volume−tumor volume)/(total liver volume−tumor volume) and functional future remnant liver volume/functional total liver volume, respectively. Results: Before PVE, the correlation was strongly significant between %LV and %FLV of the non-embolized liver, and the data were nearly equal (the regression coefficient was 1.005, P<0.0001). In contrast, after PVE, there was a significant correlation between %LV and %FLV (P<0.0001), but the regression coefficient was 1.192. The % LV increased significantly, from 38.1 to 52.0%, and the increment was 13.9% (P<0.0005). The %FLV was also increased significantly, from 36.6 to 58.0%, and the increment was 21.4% (P<0.0001). The increment was 7.5% greater for the %FLV compared to that of the %LV (P<0.001). Conclusions: The 99mTc-GSA scintigraphy SPECT-CT fusion system can estimate the correct functional liver volume and is useful in comparison with conventional CT volumetry. Springer, 2011 Portal vein embolization nationallicence 99mTc-Galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system nationallicence Functional liver volume nationallicence HCC : Hepatocellular carcinoma nationallicence PVE : Portal vein embolization nationallicence %LV : Percentage of non-tumorous remnant liver volume nationallicence %FLV : Percentage of functional remnant liver volume nationallicence SPECT : Single-photon emission computed tomography nationallicence 99mTc-GSA scintigraphy : 99mTc-galactosyl human serum albumin scintigraphy nationallicence LHL 15 : Uptake ratio of the liver to the liver plus heart at 15min nationallicence ICG R15 : Indocyanine green retention rate at 15min nationallicence Beppu Toru Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Hayashi Hiromitsu Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Okabe Hirohisa Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Masuda Toshiro Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Mima Kosuke Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Otao Ryu Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Chikamoto Akira Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Doi Koichi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Ishiko Takatoshi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Takamori Hiroshi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Yoshida Morikatsu Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Shiraishi Shinya Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Yamashita Yasuyuki Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Baba Hideo Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 938-943 0944-1174 46:7<938 2011 46 535 https://doi.org/10.1007/s00535-011-0406-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0406-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beppu Toru Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hayashi Hiromitsu Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Okabe Hirohisa Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Masuda Toshiro Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Mima Kosuke Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Otao Ryu Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Chikamoto Akira Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Doi Koichi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ishiko Takatoshi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Takamori Hiroshi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Yoshida Morikatsu Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Shiraishi Shinya Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Yamashita Yasuyuki Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Baba Hideo Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 938-943 0944-1174 46:7<938 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer