caa a22 4500 445888148 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00535-011-0400-3 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0400-3 Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model [Elektronische Daten] [Michitaka Honda, Tatsuo Nakamura, Yoshio Hori, Yoshiki Shionoya, Kazumichi Yamamoto, Yuji Nishizawa, Fumitsugu Kojima, Keiji Shigeno] Background: Intralesional or systemic steroid administration is a promising strategy for the prevention of esophageal stricture after endoscopic therapy. The aim of this study was to evaluate the influence of steroid therapy on the process of healing of defects in the esophageal mucosa after endoscopic mucosal resection (EMR). Methods: Nine beagle dogs were divided into three equal groups: group A, intralesional injection (n=3), group B, peroral administration (n=3), and group C, untreated control (n=3). In group A, triamcinolone acetonide 1ml (10mg) was injected directly into the exposed submucosal layer immediately after EMR, and again on postoperative day (POD) 7. In group B, dogs were administered prednisolone 0.5mg/kg/day orally for 14days after EMR. In group C, 1ml normal saline was injected by the same method as that used for group A. On POD 28, histological examination was performed to evaluate epithelialization, inflammation, angiogenesis, and atrophy of the muscularis propria. Results: In groups A, B, and C, the mean ulcer area was 50.1, 22.7, and 7.4mm2, respectively. The difference between groups A and C was significant (p<0.01). Inflammatory cells were significantly more evident in the lesions of group A than in those of group C (p<0.05). In all groups, atrophy of the muscularis propria was evident. However, transmural destruction and fibrosis were observed only in group A. Conclusion: It was speculated that the esophageal ulcer causes the fibrosis of the submucosa and atrophy of the muscularis propria during process of healing. Intralesional steroid injection deepened the esophageal ulcers and delayed epithelialization, whereas systemic administration did not clearly improve the lesion healing process. Springer, 2011 Steroid nationallicence Endoscopic mucosal resection nationallicence Esophageal stricture nationallicence Honda Michitaka Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Nakamura Tatsuo Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Hori Yoshio Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Shionoya Yoshiki Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Yamamoto Kazumichi Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Nishizawa Yuji Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Kojima Fumitsugu Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Shigeno Keiji Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 866-872 0944-1174 46:7<866 2011 46 535 https://doi.org/10.1007/s00535-011-0400-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0400-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Honda Michitaka Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Nakamura Tatsuo Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Hori Yoshio Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Shionoya Yoshiki Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamamoto Kazumichi Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Nishizawa Yuji Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Kojima Fumitsugu Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Shigeno Keiji Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 866-872 0944-1174 46:7<866 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer