caa a22 4500 445888164 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00535-011-0413-y doi (NATIONALLICENCE)springer-10.1007/s00535-011-0413-y Current molecular markers for gastric progenitor cells and gastric cancer stem cells [Elektronische Daten] [Xiaotan Qiao, Deborah Gumucio] Gastric stem and progenitor cells (GPC) play key roles in the homeostatic renewal of gastric glands and are instrumental in epithelial repair after injury. Until very recently, the existence of GPC could only be inferred by indirect labeling strategies. The last few years have seen significant progress in the identification of biomarkers that allow prospective identification of GPC. The analysis of these unique cell populations is providing new insights into the molecular underpinnings of gastric epithelial homeostasis and repair. Of closely related interest is the potential to identify so-called cancer stem cells, a rare subpopulation of tumor-initiating cells. Here, we review the current useful biomarkers for GPC, including: (a) those that have been demonstrated by lineage tracing to give rise to all gastric cell lineages (e.g., the villin-transgene marker as well as Lgr5); (b) those that give rise to a subset of gastric lineages (e.g., TFF2); (c) markers that recognize cryptic progenitors for metaplasia (e.g., MIST1), and (d) markers that have not yet been analyzed by lineage tracing (e.g., DCKL1/DCAMKL1, CD133/PROM1, and CD44). The study of these markers has been mostly limited to the mouse model, but the hope is that the rapid pace of recent breakthroughs in this animal model will soon lead to a greater understanding of human gastric stem cell biology and to new insights into gastric cancer, the second leading cause of cancer-related death worldwide. Springer, 2011 Stomach cancer nationallicence Homeostasis nationallicence Villin nationallicence Lgr5 nationallicence Biomarker nationallicence Qiao Xiaotan Department of Cell and Developmental Biology, University of Michigan Medical School, 2045 Biomedical Science Research Building, 109 Zina Pitcher Place, 48109-2200, Ann Arbor, MI, USA aut Gumucio Deborah Department of Cell and Developmental Biology, University of Michigan Medical School, 2045 Biomedical Science Research Building, 109 Zina Pitcher Place, 48109-2200, Ann Arbor, MI, USA aut Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 855-865 0944-1174 46:7<855 2011 46 535 https://doi.org/10.1007/s00535-011-0413-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0413-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qiao Xiaotan Department of Cell and Developmental Biology, University of Michigan Medical School, 2045 Biomedical Science Research Building, 109 Zina Pitcher Place, 48109-2200, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Gumucio Deborah Department of Cell and Developmental Biology, University of Michigan Medical School, 2045 Biomedical Science Research Building, 109 Zina Pitcher Place, 48109-2200, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/7(2011-07-01), 855-865 0944-1174 46:7<855 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer