caa a22 4500 445888202 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00535-011-0452-4 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0452-4 Percutaneous radiofrequency ablation therapy for hepatocellular carcinoma: a proposed new grading system for the ablative margin and prediction of local tumor progression and its validation [Elektronische Daten] [Hiroki Nishikawa, Tadashi Inuzuka, Haruhiko Takeda, Jun Nakajima, Azusa Sakamoto, Sinichiro Henmi, Fumihiro Matsuda, Yuji Eso, Tetsuro Ishikawa, Sumio Saito, Ryuichi Kita, Toru Kimura, Yukio Osaki] Background: In the present study we classified the radicality of percutaneous radiofrequency thermal ablation (RFA) therapy according to the extent of the ablated margin. We measured the local recurrence rate for each radicality grade to evaluate the significance of the grading system in assessing the therapeutic effectiveness of RFA and predicting local tumor progression. Methods: This retrospective study involved 269 patients with solitary hypervascular hepatocellular carcinoma who had undergone RFA. The mean±SD observation period after RFA, number of treatment sessions, and tumor diameter were 25.7±19.9months, 1.2±0.5, and 2.1±0.7cm, respectively. Patients were evaluated using dynamic computed tomography. We classified the radicality of RFA treatment into four grades (R grades: A, B, C, and D) according to the extent of the ablated tumor margin, calculated the post-RFA cumulative local recurrence rate for each R grade, and analyzed the factors (patient characteristics, biochemical data, contiguous vessels, and tumor marker) contributing to local recurrence. Results: The cumulative local recurrence rates at 3years were 6.7, 17.6, 55.8, and 82.2% for Grades A, B, C, and D, respectively. Using univariate analysis, R grade, tumor size (>2cm), and des-γ-carboxy prothrombin (DCP) (>200mAU/mL) were shown to be significant factors contributing to local recurrence. However, using multivariate analysis, only the R grade was found to be a significant independent factor. Conclusions: The proposed R grading method is a valid and useful method for assessing treatment efficacy, and for predicting local tumor progression after RFA. Springer, 2011 Hepatocellular carcinoma nationallicence Radiofrequency thermal ablation nationallicence Treatment outcome nationallicence Grading nationallicence Local tumor progression nationallicence Nishikawa Hiroki Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Inuzuka Tadashi Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Takeda Haruhiko Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Nakajima Jun Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Sakamoto Azusa Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Henmi Sinichiro Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Matsuda Fumihiro Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Eso Yuji Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Ishikawa Tetsuro Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Saito Sumio Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Kita Ryuichi Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Kimura Toru Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Osaki Yukio Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1418-1426 0944-1174 46:12<1418 2011 46 535 https://doi.org/10.1007/s00535-011-0452-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0452-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishikawa Hiroki Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Inuzuka Tadashi Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Takeda Haruhiko Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Nakajima Jun Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Sakamoto Azusa Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Henmi Sinichiro Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Matsuda Fumihiro Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Eso Yuji Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Ishikawa Tetsuro Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Saito Sumio Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Kita Ryuichi Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Kimura Toru Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 700 1- Osaki Yukio Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, 543-0027, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1418-1426 0944-1174 46:12<1418 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer