caa a22 4500 445888210 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00535-011-0494-7 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0494-7 Pancreatic cancer stem cell biology and its therapeutic implications [Elektronische Daten] [Filip Bednar, Diane Simeone] Pancreatic cancer remains one of the most difficult malignancies to treat. Significant developments in our understanding of pancreatic cancer biology have occurred over the past decade. One of the key advances has been the formulation of the cancer stem cell model of tumor growth and subsequent experimental proof of pancreatic cancer stem cell existence. Cancer stem cells contribute to pancreatic tumor growth and progression and are at least partially responsible for the relative resistance of the tumor to systemic chemotherapy and radiation. Significant questions remain about how the mutational profile of the tumor, the tumor microenvironment, and normal pancreatic developmental pathways contribute to pancreatic cancer stem cell biology. Answers to these questions will likely yield new therapeutic approaches for this deadly disease. Springer, 2011 Pancreatic cancer nationallicence Cancer stem cells nationallicence Therapeutic resistance nationallicence Epithelial-mesenchymal transition nationallicence Bednar Filip Departments of Surgery and Physiology TC 2210B, Box 5343, University of Michigan Medical Center, 1500 E. Medical Center Dr., 48109, Ann Arbor, MI, USA aut Simeone Diane Departments of Surgery and Physiology TC 2210B, Box 5343, University of Michigan Medical Center, 1500 E. Medical Center Dr., 48109, Ann Arbor, MI, USA aut Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1345-1352 0944-1174 46:12<1345 2011 46 535 https://doi.org/10.1007/s00535-011-0494-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0494-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bednar Filip Departments of Surgery and Physiology TC 2210B, Box 5343, University of Michigan Medical Center, 1500 E. Medical Center Dr., 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Simeone Diane Departments of Surgery and Physiology TC 2210B, Box 5343, University of Michigan Medical Center, 1500 E. Medical Center Dr., 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1345-1352 0944-1174 46:12<1345 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer