caa a22 4500 445888229 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00535-011-0458-y doi (NATIONALLICENCE)springer-10.1007/s00535-011-0458-y The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection [Elektronische Daten] [Viola Weich, Eva Herrmann, Tje Chung, Christoph Sarrazin, Holger Hinrichsen, Peter Buggisch, Tilman Gerlach, Hartwig Klinker, Ulrich Spengler, Alexandra Bergk, Stefan Zeuzem, Thomas Berg] Background: The critical analysis of baseline factors has been found to be useful to predict virologic nonresponse (NR), relapse, or sustained virologic response (SVR) in patients infected with hepatitis C virus (HCV) who receive antiviral therapy. In the present retrospective study we tried to find out whether gamma-glutamyltranspeptidase (GGT) may be one of the baseline factors which are of special predictive power. We analyzed, in patients with different treatment outcomes, the predictive power of established baseline factors either in combination with GGT or by evaluating the predictive value of GGT independently. Methods: Individual data from 632 patients chronically infected with HCV type 1 (n=561) or type 2/3 (n=71) were analyzed. All patients had received their first course of antiviral therapy and were treated with pegylated interferon α-2a or -2b plus ribavirin. Results: In patients with HCV type 1, a multivariate multinomial logistic regression analysis identified low GGT (p<0.0001), high cholesterol (p<0.0001), age ≤40years (p<0.0001), high alanine aminotransferase (p=0.0006), low viremia (p=0.0014), and absence of cirrhosis (p=0.0164) as independent predictors. While these baseline factors heralded improved virologic response, high GGT, in contrast, was significantly associated with NR (p<0.0001). A strong correlation was found between log10 GGT and a scoring variable S (r=−0.26 for prediction of SVR, p<0.001; r=0.11 for prediction of NR, p=0.016) summarizing predictive information from other baseline factors. Conclusions: These findings prove the predictive sensitivity of GGT as an independent indicator of nonresponsiveness even at levels that are slightly above the normal range. This new predictive parameter may help to improve individualized therapy in HCV type-1 infection. Springer, 2011 Antiviral therapy nationallicence Baseline factors nationallicence Virologic nonresponse nationallicence End-of-treatment response nationallicence Sustained virologic response nationallicence HCV : Hepatitis C virus nationallicence IFN : Interferon nationallicence RBV : Ribavirin nationallicence GGT : Gamma-glutamyltranspeptidase nationallicence ALT : Alanine aminotransferase nationallicence AST : Aspartate aminotransferase nationallicence AP : Alkaline phosphatase nationallicence WBC : White blood count nationallicence IgA : Immune globulin A nationallicence pCHE : Pseudocholinesterase nationallicence BMI : Body mass index nationallicence SVR : Sustained virologic response nationallicence SR : Sustained response nationallicence NR : Nonresponse nationallicence EOT : End-of-treatment virologic response nationallicence RNA : Ribonucleic acid nationallicence DNA : Deoxyribonucleic acid nationallicence bDNA : Branched DNA nationallicence ROC : Receiver operating characteristics nationallicence ULN : Upper limit of normal nationallicence S : Scoring variable nationallicence TNF-α : Tumor necrosis factor-α nationallicence ETR : End-of-treatment virologic response nationallicence Weich Viola Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany aut Herrmann Eva Institut für Biostatistik und mathematische Modellierung, Goethe-Universität Frankfurt, Frankfurt, Germany aut Chung Tje Institut für Biostatistik und mathematische Modellierung, Goethe-Universität Frankfurt, Frankfurt, Germany aut Sarrazin Christoph Medizinische Klinik 1, Klinikum der Goethe-Universität Frankfurt, Frankfurt, Germany aut Hinrichsen Holger Universitätsklinikum Schleswig-Holstein, Kiel, Germany aut Buggisch Peter Universitätsklinikum Eppendorf, Hamburg, Germany aut Gerlach Tilman Klinikum Augustinum München, München, Germany aut Klinker Hartwig Medizinische Klinik und Poliklinik II der Universität Würzburg, Würzburg, Germany aut Spengler Ulrich Medizinische Universitätsklinik II, Bonn, Germany aut Bergk Alexandra Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany aut Zeuzem Stefan Medizinische Klinik 1, Klinikum der Goethe-Universität Frankfurt, Frankfurt, Germany aut Berg Thomas Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany aut Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1427-1436 0944-1174 46:12<1427 2011 46 535 https://doi.org/10.1007/s00535-011-0458-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0458-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weich Viola Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Herrmann Eva Institut für Biostatistik und mathematische Modellierung, Goethe-Universität Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Chung Tje Institut für Biostatistik und mathematische Modellierung, Goethe-Universität Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Sarrazin Christoph Medizinische Klinik 1, Klinikum der Goethe-Universität Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Hinrichsen Holger Universitätsklinikum Schleswig-Holstein, Kiel, Germany aut NATIONALLICENCE 700 1- Buggisch Peter Universitätsklinikum Eppendorf, Hamburg, Germany aut NATIONALLICENCE 700 1- Gerlach Tilman Klinikum Augustinum München, München, Germany aut NATIONALLICENCE 700 1- Klinker Hartwig Medizinische Klinik und Poliklinik II der Universität Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Spengler Ulrich Medizinische Universitätsklinik II, Bonn, Germany aut NATIONALLICENCE 700 1- Bergk Alexandra Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Zeuzem Stefan Medizinische Klinik 1, Klinikum der Goethe-Universität Frankfurt, Frankfurt, Germany aut NATIONALLICENCE 700 1- Berg Thomas Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1427-1436 0944-1174 46:12<1427 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer