caa a22 4500 445888237 CHVBK 20180317145606.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00535-011-0453-3 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0453-3 Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups [Elektronische Daten] [Motohiko Kato, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Shunsuke Yamamoto, Yoshihiro Kamada, Yuichi Yoshida, Shinichi Kiso, Shusaku Tsutsui, Shinji Kihara, Norio Hayashi, Yuji Matsuzawa] Background: Obesity is a risk factor for gastro-esophageal reflux disease (GERD). It is generally considered that intra-abdominal pressure in obese subjects is involved in the pathogenesis of GERD through acid exposure to the esophagus. Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between adiponectin and erosive esophagitis. Methods: This was a cross-sectional retrospective observational study: 2405 consecutive subjects who underwent screening esophago-gastro-duodenoscopy with serum adiponectin measurement as part of their physical check-up programs were analyzed. Clinical factors were compared between subjects with and without erosive esophagitis. The association between adiponectin and erosive esophagitis was assessed using a bootstrapping re-sampling method after adjustment for factors that tended to be different in univariate analysis. Results: Serum adiponectin levels were significantly lower in those with erosive esophagitis (8.17μg/ml) than in those without (10.1). The erosive esophagitis group had a greater body mass index (BMI) and waist circumference (WC) and a higher prevalence of hiatal hernia. Using the bootstrap method, with a lower adiponectin cut-off value of 3-7μg/ml, the lower limit of the 95% confidence interval of the adjusted odds ratio consistently exceeded 1 after adjustment for BMI and hiatal hernia in men. When adjusting for WC instead of BMI, the effect of adiponectin was reduced but remained significant at a lower cut-off value (3-3.5μg/ml). Conclusions: Low serum adiponectin levels may be associated with an increased risk for erosive esophagitis in men. Springer, 2011 Esophagitis nationallicence Adiponectin nationallicence Obesity nationallicence Kato Motohiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Watabe Kenji Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Hamasaki Toshimitsu Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Suita, Japan aut Umeda Miyuki Sumitomo Hospital, Osaka, Japan aut Furubayashi Aiko Sumitomo Hospital, Osaka, Japan aut Kinoshita Kazuo Sumitomo Hospital, Osaka, Japan aut Kishida Osamu Sumitomo Hospital, Osaka, Japan aut Fujimoto Takashi Sumitomo Hospital, Osaka, Japan aut Yamada Akira Sumitomo Hospital, Osaka, Japan aut Tsukamoto Yoshifumi Sumitomo Hospital, Osaka, Japan aut Yamamoto Shunsuke Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kamada Yoshihiro Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Tsutsui Shusaku Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kihara Shinji Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Japan aut Hayashi Norio Kansai Rosai Hospital, Amagasaki, Japan aut Matsuzawa Yuji Sumitomo Hospital, Osaka, Japan aut Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1361-1367 0944-1174 46:12<1361 2011 46 535 https://doi.org/10.1007/s00535-011-0453-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0453-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kato Motohiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Watabe Kenji Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hamasaki Toshimitsu Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Umeda Miyuki Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Furubayashi Aiko Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Kinoshita Kazuo Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Kishida Osamu Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Fujimoto Takashi Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Yamada Akira Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Tsukamoto Yoshifumi Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Yamamoto Shunsuke Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kamada Yoshihiro Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Tsutsui Shusaku Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kihara Shinji Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Hayashi Norio Kansai Rosai Hospital, Amagasaki, Japan aut NATIONALLICENCE 700 1- Matsuzawa Yuji Sumitomo Hospital, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/12(2011-12-01), 1361-1367 0944-1174 46:12<1361 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer