caa a22 4500 44588827X CHVBK 20180317145606.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00535-010-0347-9 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0347-9 The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori [Elektronische Daten] [Susumu Take, Motowo Mizuno, Kuniharu Ishiki, Tomowo Yoshida, Nobuya Ohara, Kenji Yokota, Keiji Oguma, Hiroyuki Okada, Kazuhide Yamamoto] Background: We previously reported that eradication of Helicobacter pylori reduced the risk of developing gastric cancer in patients with peptic ulcer diseases. In the present study, we further followed up our patient group to investigate the occurrence and clinical features of gastric cancers that developed after cure of the infection. Methods: Prospective post-eradication evaluations were conducted on 1674 consecutive patients who had received successful H. pylori eradication therapy. The patients had undergone endoscopic examination before eradication therapy to evaluate peptic ulcers, background gastric mucosal atrophy, and H. pylori infection. After confirmation of cure of the infection, follow-up endoscopy was performed yearly. Results: The patients were followed for up to 14.1years (a mean of 5.6years). During the follow-up, gastric cancer developed in 28 of the 1674 patients as long as 13.7years after the cure of H. pylori infection. The risk of developing gastric cancer was 0.30% per year. Histologically, 16 of the gastric cancers were the intestinal type and 12 were the diffuse type; the risk of each cancer type was 0.17 and 0.13% per year, respectively. There was no significant inflammatory cell infiltration in the background gastric mucosa at the time the cancers were recognized. Conclusion: There is a risk of developing gastric cancer of both the intestinal and diffuse types even after the cure of H. pylori infection and extinction of gastric inflammation. It is important to inform patients about the risk of gastric cancer after eradication therapy and offer them surveillance endoscopy. Springer, 2010 Eradication therapy nationallicence Gastric cancer nationallicence Helicobacter pylori nationallicence Take Susumu Department of Internal Medicine, Fukuwatari Municipal Hospital, 1000 Fukuwatari, Takebe-cho, Kitaku, 709-3111, Okayama, Japan aut Mizuno Motowo Department of Gastrointestinal Endoscopy, Hiroshima City Hospital, 7-33 Motomachi, Nakaku, 730-8518, Hiroshima, Japan aut Ishiki Kuniharu Department of Internal Medicine, Nippon Kokan Fukuyama Hospital, 1840 Tsunoshita, Daimon-cho, 721-0927, Fukuyama, Japan aut Yoshida Tomowo Department of Internal Medicine, Nippon Kokan Fukuyama Hospital, 1840 Tsunoshita, Daimon-cho, 721-0927, Fukuyama, Japan aut Ohara Nobuya Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut Yokota Kenji Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut Oguma Keiji Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut Okada Hiroyuki Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut Yamamoto Kazuhide Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 318-324 0944-1174 46:3<318 2011 46 535 https://doi.org/10.1007/s00535-010-0347-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0347-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Take Susumu Department of Internal Medicine, Fukuwatari Municipal Hospital, 1000 Fukuwatari, Takebe-cho, Kitaku, 709-3111, Okayama, Japan aut NATIONALLICENCE 700 1- Mizuno Motowo Department of Gastrointestinal Endoscopy, Hiroshima City Hospital, 7-33 Motomachi, Nakaku, 730-8518, Hiroshima, Japan aut NATIONALLICENCE 700 1- Ishiki Kuniharu Department of Internal Medicine, Nippon Kokan Fukuyama Hospital, 1840 Tsunoshita, Daimon-cho, 721-0927, Fukuyama, Japan aut NATIONALLICENCE 700 1- Yoshida Tomowo Department of Internal Medicine, Nippon Kokan Fukuyama Hospital, 1840 Tsunoshita, Daimon-cho, 721-0927, Fukuyama, Japan aut NATIONALLICENCE 700 1- Ohara Nobuya Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut NATIONALLICENCE 700 1- Yokota Kenji Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut NATIONALLICENCE 700 1- Oguma Keiji Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut NATIONALLICENCE 700 1- Okada Hiroyuki Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut NATIONALLICENCE 700 1- Yamamoto Kazuhide Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, 700-8558, Okayama, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 318-324 0944-1174 46:3<318 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer