caa a22 4500 445888288 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00535-010-0301-x doi (NATIONALLICENCE)springer-10.1007/s00535-010-0301-x Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C [Elektronische Daten] [Hiroyasu Morikawa, Katsuhiko Fukuda, Sawako Kobayashi, Hideki Fujii, Shuji Iwai, Masaru Enomoto, Akihiro Tamori, Hiroki Sakaguchi, Norifumi Kawada] Background : Although histopathological examination by "invasive” liver biopsy remains the gold standard for evaluating disease progression in chronic liver disease, noninvasive tools have appeared and have led to great progress in diagnosing the stage of hepatic fibrosis. The aim of this study was to assess the value of real-time tissue elastography, using an instrument made in Japan, for the visible measurement of liver elasticity; in particular, comparing the results with those of transient elastography (Fibroscan). Methods: Real-time tissue elastography (RTE), transient elastography (Fibroscan), liver biopsy, and routine laboratory analyses were performed in 101 patients with chronic hepatitis C. The values for tissue elasticity obtained using novel software (Elasto_ver 1.5.1) connected to RTE were transferred to four image features, Mean, Standard Deviation (SD), Area, and Complexity. Their association with the stage of fibrosis at biopsy and with liver stiffness (kPa) obtained by Fibroscan was analyzed. Results: Colored images obtained by RTE were classified into diffuse soft, intermediate, and patchy hard patterns and the calculated elasticity differed significantly between patients according to and correlated with the stages of fibrosis (p<0.0001). Mean, SD, Area, and Complexity showed significant differences between the stages of fibrosis (Tukey-Kramer test, p<0.05). In discriminating patients with cirrhosis, the areas under the receiver operating characteristic curves (AUC) were 0.91 for Mean, 0.84 for SD, 0.91 for Area, 0.93 for Complexity, and 0.95 for Fibroscan. Conclusions: RTE is a noninvasive instrument for the colored visualization of liver elasticity in patients with chronic liver disease. Springer, 2010 Liver fibrosis nationallicence Transient elastography nationallicence Ultrasound nationallicence Liver biopsy nationallicence Morikawa Hiroyasu Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Fukuda Katsuhiko Department of Gastroenterology, PL Hospital, Tondabayashi, Japan aut Kobayashi Sawako Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Fujii Hideki Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Iwai Shuji Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Enomoto Masaru Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Tamori Akihiro Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Sakaguchi Hiroki Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Kawada Norifumi Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 350-358 0944-1174 46:3<350 2011 46 535 https://doi.org/10.1007/s00535-010-0301-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0301-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morikawa Hiroyasu Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Fukuda Katsuhiko Department of Gastroenterology, PL Hospital, Tondabayashi, Japan aut NATIONALLICENCE 700 1- Kobayashi Sawako Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Fujii Hideki Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Iwai Shuji Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Enomoto Masaru Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Tamori Akihiro Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Sakaguchi Hiroki Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 700 1- Kawada Norifumi Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, 545-8585, Abeno, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 350-358 0944-1174 46:3<350 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer