caa a22 4500 445888318 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00535-010-0313-6 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0313-6 Different effect of HBV vaccine after liver transplantation between chronic HBV carriers and non-HBV patients who received HBcAb-positive grafts [Elektronische Daten] [Masatoshi Ishigami, Hideya Kamei, Taro Nakamura, Yoshiaki Katano, Hisami Ando, Tetsuya Kiuchi, Hidemi Goto] Background: Combination of nucleos(t)ide analogue and anti-HBs immunoglobulin (HBIg) is the standard protocol for prevention of HBV reactivation after liver transplantation, but because of the extremely high cost of HBIg, HBV vaccine is tried as a much cheaper and potentially safer substitute. Here we show the different effect of HBV vaccine between chronic HBV carrier and non-HBV patients who received grafts from HBc antibody-positive donors. Methods: Fifteen chronic HBV carriers and 6 non-HBV patients who received grafts from HBc antibody-positive donors were included in this study. These patients received double dose of pre-S-containing HBV vaccine every month from later than 12months after liver transplantation. Successful vaccination was defined as HBsAb >100IU/l without HBIg administration for 3months. Results: None of the 15 chronic HBV carriers succeeded in maintaining high enough HBsAb titers. In contrast, 5 of 6 non-HBV patients with HBcAb-positive donors achieved HBsAb >100IU/l without HBIg coadministration. Recipient HBV status (HBV carrier/non-HBV) was considered to have a stronger effect on vaccine success (p<0.001) though recipient age (p=0.006) was also selected as a significant factor. Conclusions: Recipient HBV status seems to be the most important factor affecting success of HBV vaccine after liver transplantation. In non-HBV patients who received grafts from HBcAb-positive donors, HBV vaccination is an effective, cost-saving, and safe method for prevention of HBV reactivations. In contrast in chronic HBV patients, response rate was quite poor, so some modifications such as combination with adjuvant or modification of administration schedules should be considered. Springer, 2010 HBV vaccine nationallicence Liver transplantation nationallicence HBV carriers nationallicence HBcAb-positive donors nationallicence HBV : Hepatitis B virus nationallicence HBsAg : Hepatitis B surface antigen nationallicence HBcAb : Hepatitis B core antibody nationallicence HBsAb : Hepatitis B surface antibody nationallicence Ishigami Masatoshi Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Kamei Hideya Department of Transplant Surgery, Nagoya University School of Medicine, Nagoya, Japan aut Nakamura Taro Department of Transplant Surgery, Nagoya University School of Medicine, Nagoya, Japan aut Katano Yoshiaki Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Ando Hisami Department of Pediatric Surgery, Nagoya University School of Medicine, Nagoya, Japan aut Kiuchi Tetsuya Department of Transplant Surgery, Nagoya University School of Medicine, Nagoya, Japan aut Goto Hidemi Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 367-377 0944-1174 46:3<367 2011 46 535 https://doi.org/10.1007/s00535-010-0313-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0313-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishigami Masatoshi Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Kamei Hideya Department of Transplant Surgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Nakamura Taro Department of Transplant Surgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Katano Yoshiaki Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Ando Hisami Department of Pediatric Surgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Kiuchi Tetsuya Department of Transplant Surgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Goto Hidemi Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 367-377 0944-1174 46:3<367 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer