caa a22 4500 445888377 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00535-010-0306-5 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0306-5 A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma: a prospective randomized trial [Elektronische Daten] [Takahiro Yamasaki, Satoe Hamabe, Issei Saeki, Yohei Harima, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida] Background: We designed a novel transcatheter arterial infusion chemotherapy (TAI) using iodized oil (lipiodol) and degradable starch microspheres (DSM) for hepatocellular carcinoma (HCC) patients. In this study, we investigated the efficacy of TAI using lipiodol and DSM in a prospective randomized trial. Methods: We randomly divided 45 patients with HCC into 3 groups: TAI using lipiodol (lipiodol group, n=15), TAI using DSM (DSM group, n=15), and TAI using lipiodol and DSM (lipiodol+DSM group, n=15). In the lipiodol group, a mixture of cisplatin and lipiodol was administered. In the DSM group, a mixture of cisplatin and DSM was administered. In the lipiodol+DSM group, a mixture of cisplatin and lipiodol was administered, followed by DSM. Results: The response rates were 40% in the lipiodol group, 53.4% in the DSM group, and 80% in the lipiodol+DSM group, respectively. The response rate tended to improve in the lipiodol+DSM group (lipiodol group vs. lipiodol+DSM group, P=0.07). The median progression-free survival time was 177days in the lipiodol group, 287days in the DSM group, and 377days in the lipiodol+DSM group. The progression-free survival in the lipiodol+DSM group was significantly better than those in the DSM group (P=0.020) and the lipiodol group (P=0.035). There were no serious adverse effects among the 3 groups. Conclusions: TAI using lipiodol and DSM was superior to TAI using lipiodol only and TAI using DSM only because of improvements in therapeutic effects and progression-free survival. Springer, 2010 Hepatocellular carcinoma nationallicence Transcatheter arterial infusion chemotherapy nationallicence Iodized oil nationallicence Degradable starch microspheres nationallicence Randomized trial nationallicence Yamasaki Takahiro Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Hamabe Satoe Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Saeki Issei Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Harima Yohei Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Yamaguchi Yuhki Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Uchida Koichi Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Terai Shuji Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Sakaida Isao Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 359-366 0944-1174 46:3<359 2011 46 535 https://doi.org/10.1007/s00535-010-0306-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0306-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamasaki Takahiro Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Hamabe Satoe Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Saeki Issei Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Harima Yohei Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Yamaguchi Yuhki Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Uchida Koichi Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Terai Shuji Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Sakaida Isao Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 359-366 0944-1174 46:3<359 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer