caa a22 4500 445888415 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00535-010-0354-x doi (NATIONALLICENCE)springer-10.1007/s00535-010-0354-x Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy [Elektronische Daten] [Hyo-Suk Lee, Byung Yoo, Kwan Lee, Ju Kim, Soon-Ho Um, Soo Ryu, Young-Suk Lee, Young Kim, Kwon Yoo, Joon-Yeol Han, Jae Hwang, Tae-Hun Kim, Jin-Mo Yang, Heon-Ju Lee, Chae Chon, Mong Cho, Byung Han, Seong Hwang, Kwan Byun, Young-Hwa Chung, Se-Hyun Cho, Kwang Koh, Byung-Ik Kim, Haak Kim, Seung Paik, Myung-Seok Lee, Hee-Won Yoo, Cheol Han] Background: This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment. Methods: Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA <4,700copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA <4,700copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96weeks without any treatment for hepatitis B. Results: Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA <141,500 and <4,700copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (−0.5logIU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes. Conclusions: The clevudine-induced viral response was durable in the majority of patients for 2years after the withdrawal of treatment. Springer, 2010 Hepatitis B virus nationallicence HBV DNA nationallicence ccc-DNA nationallicence HBeAg seroconversion nationallicence HBsAg loss nationallicence Lee Hyo-Suk Seoul National University Hospital, Seoul, Korea aut Yoo Byung Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Lee Kwan Yonsei University Hospital, Seoul, Korea aut Kim Ju Gachon Medical School, Incheon, Korea aut Um Soon-Ho Korea University Hospital, Seoul, Korea aut Ryu Soo Inje University Seoul Paik Hospital, Seoul, Korea aut Lee Young-Suk The Catholic University of Korea, Seoul, Korea aut Kim Young Inha University Hospital, Seoul, Korea aut Yoo Kwon Ewha Womans University Mokdong Hospital, Seoul, Korea aut Han Joon-Yeol The Catholic University of Korea, Seoul, Korea aut Hwang Jae Keimyung University Dongsan Medical Center, Daegu, Korea aut Kim Tae-Hun Ewha Womans University Mokdong Hospital, Seoul, Korea aut Yang Jin-Mo The Catholic University of Korea, Seoul, Korea aut Lee Heon-Ju Youngnam University Medical Center, Daegu, Korea aut Chon Chae Yonsei University Hospital, Seoul, Korea aut Cho Mong Pusan National University Hospital, Pusan, Korea aut Han Byung Kosin Medical School, Seoul, Korea aut Hwang Seong Bundang CHA Hospital, Pochon CHA University, Seongnam, Korea aut Byun Kwan Korea University Hospital, Seoul, Korea aut Chung Young-Hwa Asan Medical Center, Seoul, Korea aut Cho Se-Hyun The Catholic University of Korea, Seoul, Korea aut Koh Kwang Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Kim Byung-Ik Kangbuk Samsung Medical Center, Seoul, Korea aut Kim Haak Wonkwang University Hospital, Iksan, Korea aut Paik Seung Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut Lee Myung-Seok Hallym University Medical Center, Kangnam Sacred Heart Hospital, Seoul, Korea aut Yoo Hee-Won Bukwang Pharm. Co., Ltd, Seoul, Korea aut Han Cheol Korea Institute of Radiological and Medical Sciences, Seoul, Korea aut Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 410-414 0944-1174 46:3<410 2011 46 535 https://doi.org/10.1007/s00535-010-0354-x text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0354-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Hyo-Suk Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yoo Byung Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Kwan Yonsei University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Ju Gachon Medical School, Incheon, Korea aut NATIONALLICENCE 700 1- Um Soon-Ho Korea University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Ryu Soo Inje University Seoul Paik Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Young-Suk The Catholic University of Korea, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Young Inha University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yoo Kwon Ewha Womans University Mokdong Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Han Joon-Yeol The Catholic University of Korea, Seoul, Korea aut NATIONALLICENCE 700 1- Hwang Jae Keimyung University Dongsan Medical Center, Daegu, Korea aut NATIONALLICENCE 700 1- Kim Tae-Hun Ewha Womans University Mokdong Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yang Jin-Mo The Catholic University of Korea, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Heon-Ju Youngnam University Medical Center, Daegu, Korea aut NATIONALLICENCE 700 1- Chon Chae Yonsei University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Mong Pusan National University Hospital, Pusan, Korea aut NATIONALLICENCE 700 1- Han Byung Kosin Medical School, Seoul, Korea aut NATIONALLICENCE 700 1- Hwang Seong Bundang CHA Hospital, Pochon CHA University, Seongnam, Korea aut NATIONALLICENCE 700 1- Byun Kwan Korea University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Young-Hwa Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Se-Hyun The Catholic University of Korea, Seoul, Korea aut NATIONALLICENCE 700 1- Koh Kwang Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Byung-Ik Kangbuk Samsung Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Haak Wonkwang University Hospital, Iksan, Korea aut NATIONALLICENCE 700 1- Paik Seung Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Myung-Seok Hallym University Medical Center, Kangnam Sacred Heart Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yoo Hee-Won Bukwang Pharm. Co., Ltd, Seoul, Korea aut NATIONALLICENCE 700 1- Han Cheol Korea Institute of Radiological and Medical Sciences, Seoul, Korea aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/3(2011-03-01), 410-414 0944-1174 46:3<410 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer