caa a22 4500 445888504 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00535-011-0437-3 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0437-3 Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan® [Elektronische Daten] [Hirotoshi Ebinuma, Hidetsugu Saito, Mina Komuta, Keisuke Ojiro, Kanji Wakabayashi, Shingo Usui, Po-sung Chu, Rumiko Umeda, Yuka Ishibashi, Tetsurou Takayama, Masahiro Kikuchi, Nobuhiro Nakamoto, Yoshiyuki Yamagishi, Takanori Kanai, Kiyoshi Ohkuma, Michiie Sakamoto, Toshifumi Hibi] Background: Accurate evaluation of liver fibrosis in patients with chronic liver damage is required to determine the appropriate treatment. Various approaches, including laboratory tests and transient elastography, have been used to evaluate liver fibrosis. Recently, transient elastography with acoustic radiation force impulse (ARFI) has been developed and applied with conventional ultrasonography. The aim of this study was to evaluate the clinical utility of transient elastography with ARFI and to compare the results with this method and those of the Fibroscan® procedure. Methods: One hundred and thirty-one patients with liver damage, who underwent liver biopsy at our department, were enrolled prospectively in this study. Elastography with ARFI (applied with ACUSON S2000®), and Fibroscan® was performed at the same time as liver biopsy. These measurements were compared with histological findings in liver biopsy specimens, and measurement accuracy was evaluated by receiver-operating characteristic analysis. Results: Elastography values with both procedures were significantly correlated with the stages of liver fibrosis and there was little difference in the results obtained using the 2 procedures. The accuracy of differential diagnosis between no fibrosis at F0 and more than F1 stage was insufficient with ARFI, but this procedure was sufficient for diagnosing advanced fibrosis. The accuracy of ARFI was almost equivalent to that of the Fibroscan® method. Moreover, both ARFI and Fibroscan® values increased in proportion to the severity of hepatic inflammation when fibrosis stage is low, but not in proportion to the severity of steatosis. Conclusions: Transient elastography with ARFI is simple, non-invasive and useful for diagnosing the stage of fibrosis in chronic liver disease. The utility of ARFI was almost equivalent to that of the Fibroscan® method. Springer, 2011 Transient elastography nationallicence Acoustic radiation force impulse nationallicence Liver stiffness nationallicence Non-invasive nationallicence Fibrosis nationallicence ARFI : Acoustic radiation force impulse nationallicence HCC : Hepatocellular carcinoma nationallicence US : Ultrasonography nationallicence ROI : Region of interest nationallicence ROC : Receiver operating characteristic nationallicence AUROC : Area under ROC curve nationallicence Ebinuma Hirotoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Saito Hidetsugu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Komuta Mina Department of Pathology, School of Medicine, Keio University, Tokyo, Japan aut Ojiro Keisuke Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Wakabayashi Kanji Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Usui Shingo Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Chu Po-sung Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Umeda Rumiko Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Ishibashi Yuka Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Takayama Tetsurou Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Kikuchi Masahiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Nakamoto Nobuhiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Yamagishi Yoshiyuki Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Kanai Takanori Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Ohkuma Kiyoshi Department of Diagnostic Radiology, School of Medicine, Keio University, Tokyo, Japan aut Sakamoto Michiie Department of Pathology, School of Medicine, Keio University, Tokyo, Japan aut Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1238-1248 0944-1174 46:10<1238 2011 46 535 https://doi.org/10.1007/s00535-011-0437-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0437-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ebinuma Hirotoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Hidetsugu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Komuta Mina Department of Pathology, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Ojiro Keisuke Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Wakabayashi Kanji Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Usui Shingo Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Chu Po-sung Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Umeda Rumiko Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishibashi Yuka Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Takayama Tetsurou Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kikuchi Masahiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamoto Nobuhiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamagishi Yoshiyuki Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kanai Takanori Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohkuma Kiyoshi Department of Diagnostic Radiology, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Michiie Department of Pathology, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1238-1248 0944-1174 46:10<1238 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer