caa a22 4500 445888512 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00535-011-0431-9 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0431-9 Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease, alcoholic liver disease, and chronic liver disease of unknown etiology: report of the nationwide survey [Elektronische Daten] [Katsutoshi Tokushige, Etsuko Hashimoto, Yoshinori Horie, Makiko Taniai, Susumu Higuchi] Purpose: To clarify the etiology of hepatocellular carcinoma (HCC) in Japanese patients with non-viral liver disease, we performed a nationwide survey. The influence of obesity, lifestyle-related diseases, and alcohol consumption was focused on. Methods: A nationwide survey of 14,530 HCC patients was conducted in 2009. Clinical features were studied for HCC patients with nonalcoholic fatty liver disease (NAFLD-HCC; n=292), alcoholic liver disease (ALC-HCC; n=991), and chronic liver disease of unknown etiology (unknown HCC; n=614). The unknown HCC was divided into two subgroups, a no alcohol intake group and a modest alcohol intake group. Results: ALC-HCC accounted for 7.2% of all HCC, followed by unknown HCC (5.1%) and NAFLD-HCC (2.0%). The characteristics of these three groups were clearly different (median age was 72years for NAFLD-HCC, 68years for ALC-HCC, and 73years for unknown HCC, p<0.01; female gender was 38, 4, and 37%, respectively, p<0.01). Obesity and lifestyle-related diseases were significantly more frequent in NAFLD-HCC than in ALC-HCC and unknown HCC. The no alcohol intake subgroup of unknown HCC showed female predominance (58%) and was older, without a high prevalence of obesity and lifestyle-related diseases. In contrast, the modest alcohol intake subgroup showed the same trends regarding gender, body mass index, prevalence of lifestyle-related diseases, and liver function as the ALC-HCC group. Conclusions: The clinical features of ALC-HCC, NAFLD-HCC, and unknown HCC were clearly different. Modest intake of alcohol might have a more significant role in hepatic carcinogenesis than is presently thought. Springer, 2011 Hepatocellular carcinoma nationallicence Alcoholic liver disease nationallicence Nonalcoholic fatty liver disease nationallicence Questionnaire survey nationallicence Tokushige Katsutoshi Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Hashimoto Etsuko Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Horie Yoshinori Department of Internal Medicine, International University of Health and Welfare, Sanno Hospital, Tokyo, Japan aut Taniai Makiko Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Higuchi Susumu National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan aut Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1230-1237 0944-1174 46:10<1230 2011 46 535 https://doi.org/10.1007/s00535-011-0431-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0431-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tokushige Katsutoshi Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Hashimoto Etsuko Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Horie Yoshinori Department of Internal Medicine, International University of Health and Welfare, Sanno Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Taniai Makiko Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Higuchi Susumu National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1230-1237 0944-1174 46:10<1230 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer