caa a22 4500 445888539 CHVBK 20180317145607.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00535-011-0442-6 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0442-6 Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges [Elektronische Daten] [Dyah Dewi, Hideshi Ishii, Yoshihiro Kano, Shinpei Nishikawa, Naotsugu Haraguchi, Daisuke Sakai, Taroh Satoh, Yuichiro Doki, Masaki Mori] A growing body of evidence supports the notion that malignant tumors are heterogeneous and contain diverse subpopulations of cells with unique characteristics including the ability to initiate a tumor and metastasize. This phenomenon might be explained by the so-called cancer stem cell (CSC) theory. Recent technological developments have allowed a deeper understanding and characterization of CSCs. Even though the application of this theory to hematopoietic malignancies and solid tumors holds promise for new ways to treat cancer, it also brings some skepticism. Efficacious therapeutic approaches targeting the CSC population should be explored to overcome therapeutic failure and improve patient outcomes. This review will focus on the intrinsic and extrinsic regulation of CSCs, as well as the development of therapeutic approaches against CSCs, predominantly focusing on gastrointestinal malignancies. Springer, 2011 Gastrointestinal cancer nationallicence Cancer stem cell nationallicence Epigenetic nationallicence Microenvironment nationallicence Dewi Dyah Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Ishii Hideshi Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Kano Yoshihiro Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Nishikawa Shinpei Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Haraguchi Naotsugu Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Sakai Daisuke Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Satoh Taroh Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Doki Yuichiro Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Mori Masaki Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1145-1157 0944-1174 46:10<1145 2011 46 535 https://doi.org/10.1007/s00535-011-0442-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0442-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dewi Dyah Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ishii Hideshi Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kano Yoshihiro Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Nishikawa Shinpei Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Haraguchi Naotsugu Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Sakai Daisuke Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Satoh Taroh Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Doki Yuichiro Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Mori Masaki Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1145-1157 0944-1174 46:10<1145 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer