caa a22 4500 445888555 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00535-011-0441-7 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0441-7 Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis [Elektronische Daten] [Jie Liang, Shengjun Wu, Bin Feng, Shaoni Lei, Guanhong Luo, Jingbo Wang, Kai Li, Xiaohua Li, Huahong Xie, Dexin Zhang, Xin Wang, Kaichun Wu, Danmin Miao, Daiming Fan] Background: Recent studies proved that inflammatory bowel disease (IBD) patients had a higher risk of thromboembolism and a Factor V Leiden mutation that prevents the efficient inactivation of factor V, which leads to thromboembolism and thus contributes to a high potential risk of IBD. However, the relationship between Factor V Leiden mutation and IBD remains controversial. Methods: We conducted a systematic review with meta-analysis of studies assessing the association of Factor V Leiden mutation with the risk of IBD in humans. We extracted the number of IBD and control subjects with or without Factor V Leiden mutation from each study and conducted this analysis using a fixed-effects model. Results: Nineteen studies met the inclusion criteria and were included in the meta-analysis. No significant heterogeneity was found in results across the 19 studies (I 2=18.8%, P=0.23), which showed a slight but not significant increase in the risk of IBD with Factor V Leiden mutation in the general population (summary odds ratio [OR] 1.13, 95% confidence interval [CI] 0.87-1.46). Taking into account ethnic differences, further study exhibited a slight but not significant increase in risk of IBD with Factor V Leiden mutation in Europeans (summary OR 1.20, 95% CI 0.88-1.64). However, Factor V Leiden mutation was significantly associated with a higher risk of thromboembolism in IBD patients (summary OR 5.30, 95% CI 2.25-12.48). No publication bias was found in this study. Conclusions: This meta-analysis indicated that although Factor V Leiden mutation was not significantly associated with the risk of IBD, it was significantly associated with a higher risk of thromboembolism in IBD patients. Springer, 2011 Factor V Leiden nationallicence Inflammatory bowel diseases nationallicence Systematic review and meta-analysis nationallicence Liang Jie State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Wu Shengjun Department of Psychology, School of Aerospace Medicine, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Feng Bin State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Lei Shaoni State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Luo Guanhong State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Wang Jingbo State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Li Kai State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Li Xiaohua State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Xie Huahong State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Zhang Dexin State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Wang Xin State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Wu Kaichun State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Miao Danmin Department of Psychology, School of Aerospace Medicine, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Fan Daiming State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1158-1166 0944-1174 46:10<1158 2011 46 535 https://doi.org/10.1007/s00535-011-0441-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0441-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liang Jie State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Wu Shengjun Department of Psychology, School of Aerospace Medicine, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Feng Bin State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Lei Shaoni State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Luo Guanhong State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Wang Jingbo State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Li Kai State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Li Xiaohua State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Xie Huahong State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Zhang Dexin State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Wang Xin State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Wu Kaichun State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Miao Danmin Department of Psychology, School of Aerospace Medicine, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 700 1- Fan Daiming State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, 710032, Xi'an, Shannxi, China aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/10(2011-10-01), 1158-1166 0944-1174 46:10<1158 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence 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