caa a22 4500 44588858X CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0340-3 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0340-3 The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease [Elektronische Daten] [Yuichiro Eguchi, Toshihiko Mizuta, Yoshio Sumida, Eriko Ishibashi, Yoichiro Kitajima, Hiroshi Isoda, Hiroko Horie, Takaya Tashiro, Eri Iwamoto, Hirokazu Takahashi, Takuya Kuwashiro, Shu Soejima, Yasunori Kawaguchi, Yasutomo Oda, Sei Emura, Ryuichi Iwakiri, Iwata Ozaki, Takahisa Eguchi, Naofumi Ono, Keizo Anzai, Kazuma Fujimoto, Shunzo Koizumi] Background: Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD. Methods: First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated. Results: There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r=0.423, P<0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level=−1.359+0.143×VFA+0.046×triglyceride+0.059×LDL, R 2=0.217, P<0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P<0.05). Conclusions: These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD. Springer, 2010 Abdominal obesity nationallicence Central obesity nationallicence Adipocytokine nationallicence Metabolic syndrome nationallicence Oxidative stress nationallicence Eguchi Yuichiro Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Mizuta Toshihiko Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Sumida Yoshio Center for Digestive Disease and Liver Disease, Nara City Hospital, Nara, Japan aut Ishibashi Eriko Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Kitajima Yoichiro Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Isoda Hiroshi Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Horie Hiroko Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut Tashiro Takaya Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut Iwamoto Eri Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut Takahashi Hirokazu Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Kuwashiro Takuya Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Soejima Shu Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Kawaguchi Yasunori Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Oda Yasutomo Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Emura Sei Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Iwakiri Ryuichi Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Ozaki Iwata Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Eguchi Takahisa Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut Ono Naofumi Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut Anzai Keizo Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Fujimoto Kazuma Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut Koizumi Shunzo Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Journal of Gastroenterology Springer Japan 46(2011-01-01), 70-78 0944-1174 46<70 2011 46 535 https://doi.org/10.1007/s00535-010-0340-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0340-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eguchi Yuichiro Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Mizuta Toshihiko Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Sumida Yoshio Center for Digestive Disease and Liver Disease, Nara City Hospital, Nara, Japan aut NATIONALLICENCE 700 1- Ishibashi Eriko Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Kitajima Yoichiro Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Isoda Hiroshi Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Horie Hiroko Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut NATIONALLICENCE 700 1- Tashiro Takaya Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut NATIONALLICENCE 700 1- Iwamoto Eri Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut NATIONALLICENCE 700 1- Takahashi Hirokazu Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Kuwashiro Takuya Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Soejima Shu Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Kawaguchi Yasunori Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Oda Yasutomo Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Emura Sei Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Iwakiri Ryuichi Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Ozaki Iwata Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Eguchi Takahisa Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut NATIONALLICENCE 700 1- Ono Naofumi Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan aut NATIONALLICENCE 700 1- Anzai Keizo Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Fujimoto Kazuma Department of Internal Medicine, Saga Medical School, Saga, Nabeshima, Japan aut NATIONALLICENCE 700 1- Koizumi Shunzo Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46(2011-01-01), 70-78 0944-1174 46<70 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer