caa a22 4500 445888628 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0333-2 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0333-2 Genetic background of autoimmune hepatitis in Japan [Elektronische Daten] [Kaname Yoshizawa, Takeji Umemura, Masao Ota] Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Several studies from ethnically different countries have clarified that the genetic predisposition to type 1 AIH is linked mainly to human leukocyte antigen (HLA)-class II genes. Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic β chain of the HLA-DR antigen. However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis. Springer, 2010 Autoimmune hepatitis nationallicence Genome-wide association study nationallicence Human leukocyte antigen nationallicence Single nucleotide polymorphisms nationallicence Tumor necrosis factor nationallicence AIH : Autoimmune hepatitis nationallicence CTLA-4 : Cytotoxic T lymphocyte antigen-4 nationallicence HLA : Human leukocyte antigen nationallicence SNPs : Single nucleotide polymorphisms nationallicence TNF-α : Tumor necrosis factor-α nationallicence Yoshizawa Kaname Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Umemura Takeji Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Ota Masao Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut Journal of Gastroenterology Springer Japan 46(2011-01-01), 42-47 0944-1174 46<42 2011 46 535 https://doi.org/10.1007/s00535-010-0333-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0333-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshizawa Kaname Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Umemura Takeji Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 700 1- Ota Masao Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46(2011-01-01), 42-47 0944-1174 46<42 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer