caa a22 4500 445888636 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0327-0 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0327-0 Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis: a Japanese nationwide randomized controlled trial [Elektronische Daten] [Toshiaki Watanabe, Yoichi Ajioka, Takayuki Matsumoto, Naoki Tomotsugu, Toru Takebayashi, Eisuke Inoue, Bunei Iizuka, Masahiro Igarashi, Yasushi Iwao, Kazuo Ohtsuka, Shin-ei Kudo, Kiyonori Kobayashi, Miwa Sada, Takayuki Matsumoto, Ichiro Hirata, Kazunari Murakami, Masakazu Nagahori, Kenji Watanabe, Nobuyuki Hida, Fumiaki Ueno, Shinji Tanaka, Mamoru Watanabe, Toshifumi Hibi] Colorectal cancer is one of the complications of ulcerative colitis (UC) and the risk of cancer increases as the duration of the disease becomes longer. Surveillance colonoscopy has been considered to be important for the early detection and early treatment of colorectal cancer, especially in longstanding UC. Because it is not always easy to detect neoplastic lesions in UC endoscopically, guidelines recommend the use of step biopsy in surveillance, in which either 4 biopsy specimens for every 10cm or a total of 33 or more biopsy specimens are obtained. However, it has been pointed out that a step biopsy obtaining several tens of biopsy specimens may not be an ideal method in terms of invasiveness to the patient or medical cost. Instead of step biopsy, recent studies report the usefulness of target biopsy, in which biopsy tissues are obtained only from regions suspected of neoplasia. Therefore, the Research Group for Intractable Inflammatory Bowel Disease of the Ministry of Health, Labour and Welfare of Japan has initiated a randomized controlled study to compare the efficacy of step biopsy and target biopsy. The present article gives an introduction to this ongoing randomized controlled trial in Japan. Springer, 2010 Ulcerative colitis nationallicence Colorectal cancer nationallicence Dysplasia nationallicence Randomized controlled trial nationallicence Colonoscopy nationallicence Watanabe Toshiaki Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut Ajioka Yoichi Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Japan aut Matsumoto Takayuki Department of Lower Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan aut Tomotsugu Naoki Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Takebayashi Toru Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Inoue Eisuke Kitasao University, 5-9-1 Shirokane, Minato-ku, 108-8641, Tokyo, Japan aut Iizuka Bunei Department of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Igarashi Masahiro Cancer Institute Ariake Hospital, 3-8-1 Ariake, Koto-ku, 135-8550, Tokyo, Japan aut Iwao Yasushi Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Ohtsuka Kazuo Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, 224-8503, Yokohama, Japan aut Kudo Shin-ei Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, 224-8503, Yokohama, Japan aut Kobayashi Kiyonori Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami, 252-0380, Sagamihara, Kanagawa, Japan aut Sada Miwa Kitasato University East Hospital, 2-1-1 Asamizodoi, Minami, 252-0380, Sagamihara, Kanagawa, Japan aut Matsumoto Takayuki Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Hirata Ichiro Fujita Health University, 1-98 Dengakugakubo, Kutsukake-Cho, 470-1192, Toyoake, Aichi, Japan aut Murakami Kazunari Department of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama-cho, Yuhu, 879-5593, Oita, Japan aut Nagahori Masakazu Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut Watanabe Kenji Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan aut Hida Nobuyuki Department of Lower Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan aut Ueno Fumiaki Department of Medicine, Ofuna Chuo Hospital, 6-2-24 Ofuna, 247-0056, Kamakura, Kanagawa, Japan aut Tanaka Shinji Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Watanabe Mamoru Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut Hibi Toshifumi Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46(2011-01-01), 11-16 0944-1174 46<11 2011 46 535 https://doi.org/10.1007/s00535-010-0327-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0327-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watanabe Toshiaki Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 700 1- Ajioka Yoichi Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Matsumoto Takayuki Department of Lower Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan aut NATIONALLICENCE 700 1- Tomotsugu Naoki Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Takebayashi Toru Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Inoue Eisuke Kitasao University, 5-9-1 Shirokane, Minato-ku, 108-8641, Tokyo, Japan aut NATIONALLICENCE 700 1- Iizuka Bunei Department of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Igarashi Masahiro Cancer Institute Ariake Hospital, 3-8-1 Ariake, Koto-ku, 135-8550, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwao Yasushi Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohtsuka Kazuo Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, 224-8503, Yokohama, Japan aut NATIONALLICENCE 700 1- Kudo Shin-ei Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, 224-8503, Yokohama, Japan aut NATIONALLICENCE 700 1- Kobayashi Kiyonori Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Sada Miwa Kitasato University East Hospital, 2-1-1 Asamizodoi, Minami, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Matsumoto Takayuki Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Hirata Ichiro Fujita Health University, 1-98 Dengakugakubo, Kutsukake-Cho, 470-1192, Toyoake, Aichi, Japan aut NATIONALLICENCE 700 1- Murakami Kazunari Department of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama-cho, Yuhu, 879-5593, Oita, Japan aut NATIONALLICENCE 700 1- Nagahori Masakazu Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut NATIONALLICENCE 700 1- Watanabe Kenji Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Hida Nobuyuki Department of Lower Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan aut NATIONALLICENCE 700 1- Ueno Fumiaki Department of Medicine, Ofuna Chuo Hospital, 6-2-24 Ofuna, 247-0056, Kamakura, Kanagawa, Japan aut NATIONALLICENCE 700 1- Tanaka Shinji Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Watanabe Mamoru Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut NATIONALLICENCE 700 1- Hibi Toshifumi Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46(2011-01-01), 11-16 0944-1174 46<11 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer