caa a22 4500 445888644 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0337-y doi (NATIONALLICENCE)springer-10.1007/s00535-010-0337-y Evaluation of risk factors for the development of cirrhosis in autoimmune hepatitis: Japanese NHO-AIH prospective study [Elektronische Daten] [Kiyoshi Migita, Yukio Watanabe, Yuka Jiuchi, Yoko Nakamura, Akira Saito, Michiyasu Yagura, Hideo Morimoto, Masaaki Shimada, Eiji Mita, Taizo Hijioka, Haruhiro Yamashita, Eiichi Takezaki, Toyokichi Muro, Hironori Sakai, Makoto Nakamuta, Seigo Abiru, Koji Yano, Atsumasa Komori, Hiroshi Yatsuhashi, Minoru Nakamura, Hiromi Ishibashi] Autoimmune hepatitis (AIH) is a chronic and progressive liver disease characterized by histological interface hepatitis and circulating autoantibodies. Our aims were to evaluate risk factors that contribute to the outcome and, particularly, the development of liver cirrhosis in a prospective multicenter cohort study of AIH. One hundred and seventy-four patients were enrolled. Histologically 21 (12.1%) had cirrhosis at the initial observation and the remaining 153 showed chronic or acute hepatitis at presentation. Among the latter 153 patients, 14 developed cirrhosis during the follow-up period (mean 8.0years). Demographic, clinical, and laboratory indices associated with the development of cirrhosis were identified. Patients who developed cirrhosis differed in mean levels of alanine aminotransferase (ALT; 158±182 vs. 441±423IU/ml) and platelet counts (14.7±5.5 vs. 19.4±6.9×104/μl) at presentation and received lower doses of corticosteroid (13.9±15.8 vs. 31.8±85.5mg/day). In a multivariate analysis, an independent predictor for progression to cirrhosis was an older age of onset (≥60years). AIH patients with cirrhosis, or those who developed cirrhosis, had a worse survival. AIH patients with an older age of onset were likely to develop cirrhosis, and careful observation and aggressive treatments are necessary for such patients. Springer, 2010 Autoimmune hepatitis nationallicence Liver cirrhosis nationallicence Multicenter cohort study nationallicence Outcome nationallicence Migita Kiyoshi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Watanabe Yukio Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Jiuchi Yuka Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Nakamura Yoko Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Saito Akira Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Yagura Michiyasu Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Morimoto Hideo Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Shimada Masaaki Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Mita Eiji Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Hijioka Taizo Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Yamashita Haruhiro Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Takezaki Eiichi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Muro Toyokichi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Sakai Hironori Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Nakamuta Makoto Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Abiru Seigo Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Yano Koji Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Komori Atsumasa Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Yatsuhashi Hiroshi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Nakamura Minoru Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Ishibashi Hiromi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut Journal of Gastroenterology Springer Japan 46(2011-01-01), 56-62 0944-1174 46<56 2011 46 535 https://doi.org/10.1007/s00535-010-0337-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0337-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Migita Kiyoshi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Watanabe Yukio Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Jiuchi Yuka Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Nakamura Yoko Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Saito Akira Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Yagura Michiyasu Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Morimoto Hideo Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Shimada Masaaki Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Mita Eiji Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Hijioka Taizo Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Yamashita Haruhiro Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Takezaki Eiichi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Muro Toyokichi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Sakai Hironori Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Nakamuta Makoto Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Abiru Seigo Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Yano Koji Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Komori Atsumasa Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Yatsuhashi Hiroshi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Nakamura Minoru Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 700 1- Ishibashi Hiromi Clinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, 856-8652, Omura, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46(2011-01-01), 56-62 0944-1174 46<56 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer