caa a22 4500 445888687 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-010-0359-5 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0359-5 Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males [Elektronische Daten] [Toshiaki Gunji, Hajime Sato, Kimiko Iijima, Kazutoshi Fujibayashi, Mitsue Okumura, Noriko Sasabe, Akio Urabe, Nobuyuki Matsuhashi] Background: The impact of obesity on gastroesophageal reflux disease remains controversial. We undertook this study, with a large sample size, to investigate risk factors for endoscopic erosive esophagitis by multivariate analysis, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) as covariates. Methods: Japanese males who visited our institute for a comprehensive medical survey between 2007 and 2010 were enrolled. All subjects voluntarily participated in a self-paid health check-up program including blood test screening, physical examinations, and esophagogastroduodenoscopy. VAT and SAT were measured by computed tomography at the navel level. Independent and significant predictors of erosive esophagitis were determined by multivariate analysis. Results: Of 9840 eligible subjects, 1831 (18.6%) were diagnosed with erosive esophagitis. Body mass index and triglyceride were predictors of an increased prevalence of erosive esophagitis (odds ratios [ORs]=1.063 and 1.001; 95% confidence intervals [CIs]=1.020-1.108 and 1.001-1.002; p=0.004 and <0.001, respectively). Heavy alcohol consumption, heavy smoking, and hiatal hernia were also associated with an increased prevalence of erosive esophagitis (ORs=1.276, 1.399, and 2.758; 95% CIs=1.085-1.501, 1.220-1.605, and 2.474-3.075; p<0.001 for all). Helicobacter pylori infection significantly and independently decreased the prevalence of erosive esophagitis (OR=0.346, 95% CI=0.299-0.401, p<0.001). Central obesity, as determined by VAT and waist girth, did not confer an increased risk of erosive esophagitis after adjusting for confounders. Conclusions: Lifestyle factors including heavy alcohol consumption, heavy smoking, metabolic disorders, and hiatal hernia increased the risk of erosive esophagitis, but central obesity did not. Springer, 2010 Erosive esophagitis nationallicence Gastroesophageal reflux disease nationallicence Central obesity nationallicence Gunji Toshiaki Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut Sato Hajime Department of Public Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut Iijima Kimiko Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut Fujibayashi Kazutoshi Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut Okumura Mitsue Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut Sasabe Noriko Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut Urabe Akio Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut Matsuhashi Nobuyuki Department of Gastroenterology, Kanto Medical Center, NTT East, 5-9-22 Higashi-gotanda, Shinagawa-ku, 141-8625, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 448-455 0944-1174 46:4<448 2011 46 535 https://doi.org/10.1007/s00535-010-0359-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0359-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gunji Toshiaki Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut NATIONALLICENCE 700 1- Sato Hajime Department of Public Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Iijima Kimiko Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujibayashi Kazutoshi Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut NATIONALLICENCE 700 1- Okumura Mitsue Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut NATIONALLICENCE 700 1- Sasabe Noriko Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut NATIONALLICENCE 700 1- Urabe Akio Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsuhashi Nobuyuki Department of Gastroenterology, Kanto Medical Center, NTT East, 5-9-22 Higashi-gotanda, Shinagawa-ku, 141-8625, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 448-455 0944-1174 46:4<448 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer