caa a22 4500 445888717 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-010-0328-z doi (NATIONALLICENCE)springer-10.1007/s00535-010-0328-z High ability to predict the treatment outcome of peginterferon and ribavirin combination therapy based on the reduction in HCV RNA levels at 4weeks after starting therapy and amino acid substitutions in the hepatitis C virus in patients infected with HCV genotype 1b [Elektronische Daten] [Hidenori Toyoda, Takashi Kumada, Seiki Kiriyama, Makoto Tanikawa, Yasuhiro Hisanaga, Akira Kanamori, Toshifumi Tada, Takahiro Arakawa, Masashi Fujimori, Takuro Niinomi, Naoto Ando, Satoshi Yasuda, Keisuke Sakai, Jun Kimura] Background: The ability to predict the outcome of peginterferon (PEG-IFN) and ribavirin combination therapy based on the reduction in hepatitis C virus (HCV) RNA levels at 4weeks after starting the therapy and amino acid substitutions in HCV was to be confirmed. Methods: We measured the reduction in HCV RNA levels at 4weeks after starting the combination therapy, as well as examining amino acid substitutions at residue 70 in the HCV core and within the interferon sensitivity-determining region (ISDR) of HCV non-structural protein 5A (NS5A), for 101 patients infected with HCV genotype 1b. The ability of these factors to predict a sustained virologic response (SVR) was analyzed. Results: When a 3 log10 reduction in HCV RNA levels at 4weeks after starting therapy was set as the cut-off value, an SVR was achieved in 37 of the 46 patients (80.4%) with a ≥3 log10 decrease and in 4 of the 55 patients (7.3%) with a <3 log10 decrease. All 4 patients who achieved an SVR despite a <3 log10 reduction in HCV RNA levels at 4weeks had an arginine at residue 70 in the HCV core and a non-wild-type sequence for the ISDR of HCV NS5A. Conclusion: A ≥3 log10 reduction in HCV RNA levels at 4weeks after starting therapy indicates that a patient has a high likelihood of achieving an SVR as a final outcome. Additional information on the amino acid substitutions at residue 70 in the HCV core and within NS5A-ISDR will further increase the ability to predict a clinical response. Springer, 2010 Chronic hepatitis C nationallicence Fourweeks nationallicence Peginterferon nationallicence Reduction in HCV RNA nationallicence Response-guided therapy nationallicence Ribavirin nationallicence Toyoda Hidenori Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Kumada Takashi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Kiriyama Seiki Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Tanikawa Makoto Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Hisanaga Yasuhiro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Kanamori Akira Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Tada Toshifumi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Arakawa Takahiro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Fujimori Masashi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Niinomi Takuro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Ando Naoto Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Yasuda Satoshi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Sakai Keisuke Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Kimura Jun Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 501-509 0944-1174 46:4<501 2011 46 535 https://doi.org/10.1007/s00535-010-0328-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0328-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toyoda Hidenori Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Kumada Takashi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Kiriyama Seiki Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Tanikawa Makoto Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Hisanaga Yasuhiro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Kanamori Akira Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Tada Toshifumi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Arakawa Takahiro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Fujimori Masashi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Niinomi Takuro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Ando Naoto Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Yasuda Satoshi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Sakai Keisuke Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Kimura Jun Department of Gastroenterology, Ogaki Municipal Hospital, 4-86 Minaminokawa, 503-8502, Ogaki, Gifu, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 501-509 0944-1174 46:4<501 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer