caa a22 4500 445888733 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-010-0336-z doi (NATIONALLICENCE)springer-10.1007/s00535-010-0336-z Alcohol drinking patterns and the risk of fatty liver in Japanese men [Elektronische Daten] [Yasunari Hiramine, Yasushi Imamura, Hirofumi Uto, Chihaya Koriyama, Masahisa Horiuchi, Makoto Oketani, Kaori Hosoyamada, Ken Kusano, Akio Ido, Hirohito Tsubouchi] Background: Alcohol is considered to be a major cause of fatty liver (FL). In contrast, however, recent investigations have suggested that moderate alcohol consumption is protective against FL. To clarify the role of alcohol consumption in FL development, we examined the association between drinking patterns and FL prevalence. Methods: We enrolled 9,886 male participants at regular medical health checks. Each subject's history of alcohol consumption was determined by questionnaire. The subjects were classified according to alcohol consumption as non-, light, moderate, and heavy drinkers (0, <20, 20-59, and ≥60g/day, respectively). FL was defined by ultrasonography. Independent predictors of FL were determined by logistic regression analysis. Results: The prevalence of FL displayed a "U-shaped curve” across the categories of daily alcohol consumption (non-, 44.7%; light, 39.3%; moderate, 35.9%; heavy drinkers, 40.1%; P<0.001). The prevalence of FL was associated positively with body mass index and other obesity-related diseases and inversely with alcohol consumption (light, odds ratio [OR] 0.71, 95% confidence interval [CI] 0.59-0.86; moderate, OR 0.55, CI 0.45-0.67; heavy, OR 0.44, CI 0.32-0.62) as determined by multivariate analysis after adjusting for potential confounding variables. In addition, examination of drinking patterns (frequency and volume) revealed that the prevalence of FL was inversely associated with the frequency of alcohol consumption (≥21days/month) (OR 0.62, CI 0.53-0.71) but not with the volume of alcohol consumed. Conclusions: Our observations suggest that alcohol consumption plays a protective role against FL in men, and consistent alcohol consumption may contribute to this favorable effect. Springer, 2010 Fatty liver nationallicence Alcohol consumption nationallicence Nonalcoholic fatty liver disease nationallicence Metabolic syndrome nationallicence Hiramine Yasunari Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan aut Imamura Yasushi Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan aut Uto Hirofumi Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut Koriyama Chihaya Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut Horiuchi Masahisa Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut Oketani Makoto Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut Hosoyamada Kaori Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan aut Kusano Ken Kagoshima Kouseiren Medical Health Care Center, Kagoshima, Japan aut Ido Akio Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut Tsubouchi Hirohito Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 519-528 0944-1174 46:4<519 2011 46 535 https://doi.org/10.1007/s00535-010-0336-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0336-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hiramine Yasunari Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan aut NATIONALLICENCE 700 1- Imamura Yasushi Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan aut NATIONALLICENCE 700 1- Uto Hirofumi Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut NATIONALLICENCE 700 1- Koriyama Chihaya Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut NATIONALLICENCE 700 1- Horiuchi Masahisa Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut NATIONALLICENCE 700 1- Oketani Makoto Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut NATIONALLICENCE 700 1- Hosoyamada Kaori Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima, Japan aut NATIONALLICENCE 700 1- Kusano Ken Kagoshima Kouseiren Medical Health Care Center, Kagoshima, Japan aut NATIONALLICENCE 700 1- Ido Akio Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut NATIONALLICENCE 700 1- Tsubouchi Hirohito Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 519-528 0944-1174 46:4<519 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer