caa a22 4500 445888741 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-011-0371-4 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0371-4 Applicability of a rapid stool antigen test, using monoclonal antibody to catalase, for the management of Helicobacter pylori infection [Elektronische Daten] [Tadashi Shimoyama, Manabu Sawaya, Atsushi Ishiguro, Norihiro Hanabata, Tetsuro Yoshimura, Shinsaku Fukuda] Background: Most monoclonal antibody-based stool antigen tests are of the "send-out” format. Rapid Testmate pylori antigen (Rapid TPAg) uses monoclonal antibody and is an "in-the-office” test. The aim of this study was to examine the usefulness of Rapid TPAg for the management of H. pylori infection. Methods: One-hundred and two consecutive patients who received H. pylori eradication therapy underwent both urea breath test (UBT) and Rapid TPAg at 5-6weeks after finishing the eradication therapy. Stool samples were maintained at −20, 5, 25, and 40°C and subjected to Rapid TPAg after 1-7days. Stool samples were also tested by enzyme immunoassay (EIA) to quantify antigenicity. Results: The agreement between Rapid TPAg and UBT in the evaluation of the results of H. pylori eradication treatment was 94.1%. The overall accuracy of Rapid TPAg and UBT to determine H. pylori eradication was 98.0 and 96.0%, respectively. The results of Rapid TPAg were not altered after storage of samples at −20 to 40°C for 7days. Antigenicity quantified by EIA did not decrease significantly after 7days. Conclusions: Rapid TPAg is a useful diagnostic test for immediate and accurate determination of the results of H. pylori eradication therapy. The antigenicity of stool sample suspensions was preserved for 7days in the collection devices. Springer, 2011 Helicobacter pylori nationallicence Stool antigen test nationallicence Eradication nationallicence Shimoyama Tadashi Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut Sawaya Manabu Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut Ishiguro Atsushi Department of Medical Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut Hanabata Norihiro Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut Yoshimura Tetsuro Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut Fukuda Shinsaku Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 487-491 0944-1174 46:4<487 2011 46 535 https://doi.org/10.1007/s00535-011-0371-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0371-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shimoyama Tadashi Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Sawaya Manabu Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Ishiguro Atsushi Department of Medical Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Hanabata Norihiro Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Yoshimura Tetsuro Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Fukuda Shinsaku Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 487-491 0944-1174 46:4<487 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer