caa a22 4500 445888784 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-010-0338-x doi (NATIONALLICENCE)springer-10.1007/s00535-010-0338-x Metabolic factors are associated with serum alanine aminotransferase levels in patients with chronic hepatitis C [Elektronische Daten] [Yumi Kobayashi, Yasunori Kawaguchi, Toshihiko Mizuta, Takuya Kuwashiro, Satoshi Oeda, Noriko Oza, Hirokazu Takahashi, Shinji Iwane, Yuichiro Eguchi, Keizo Anzai, Iwata Ozaki, Kazuma Fujimoto] Background: Although serum alanine aminotransferase (ALT) activity is an important marker for the management of chronic hepatitis C (CHC), the factors associated with serum ALT levels remain to be fully understood. This study aimed to clarify the association between serum ALT levels and clinical, histological, and virological factors in patients with CHC. Methods: We retrospectively analyzed 256 patients with CHC who underwent liver biopsy, and classified them into three groups according to serum ALT levels: normal to minimal (<40IU/L), mild (40-80IU/L), and moderate to severe elevation (≥80IU/L). All demographic and laboratory data were collected at the time of liver biopsy. All biopsies were evaluated for fibrosis, inflammation, and steatosis. Glucose metabolism was assessed by various indices derived from oral glucose tolerance tests, including the homeostasis model assessment for insulin resistance (HOMA-IR). In 180 patients, visceral fat area was measured at the umbilical level by abdominal computed tomography. Results: Ordered logistic regression analysis showed that higher serum ALT levels were significantly associated with male sex, lower high-density lipoprotein cholesterol (HDL-C), higher HOMA-IR, and higher grades of histological inflammation and steatosis. HOMA-IR, HDL-C, and hepatic steatosis were associated with visceral fat accumulation. Conclusions: Metabolic factors, as well as sex and hepatic inflammation, are independent risk factors for serum ALT elevation in hepatititis C virus (HCV)-infected patients. Metabolic factors may offer targets to decrease serum ALT levels. Springer, 2010 Alanine aminotransferase nationallicence Chronic hepatitis C nationallicence Hepatic steatosis nationallicence High-density lipoprotein cholesterol nationallicence HOMA-IR nationallicence Kobayashi Yumi Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Kawaguchi Yasunori Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Mizuta Toshihiko Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Kuwashiro Takuya Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Oeda Satoshi Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Oza Noriko Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Takahashi Hirokazu Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Iwane Shinji Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Eguchi Yuichiro Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Anzai Keizo Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Ozaki Iwata Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Fujimoto Kazuma Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 529-535 0944-1174 46:4<529 2011 46 535 https://doi.org/10.1007/s00535-010-0338-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0338-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobayashi Yumi Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Kawaguchi Yasunori Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Mizuta Toshihiko Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Kuwashiro Takuya Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Oeda Satoshi Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Oza Noriko Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Takahashi Hirokazu Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Iwane Shinji Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Eguchi Yuichiro Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Anzai Keizo Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Ozaki Iwata Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 700 1- Fujimoto Kazuma Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 529-535 0944-1174 46:4<529 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer