caa a22 4500 445888806 CHVBK 20180317145608.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-010-0349-7 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0349-7 Predictive value of tumor markers for hepatocarcinogenesis in patients with hepatitis C virus [Elektronische Daten] [Takashi Kumada, Hidenori Toyoda, Seiki Kiriyama, Makoto Tanikawa, Yasuhiro Hisanaga, Akira Kanamori, Toshifumi Tada, Junko Tanaka, Hiroshi Yoshizawa] Background: Increases in tumor markers are sometimes seen in patients with chronic liver disease without hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between the levels of three tumor markers [alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3%), and des-γ-carboxy prothrombin (DCP)] and hepatic carcinogenesis to identify hepatitis C virus (HCV) carriers at high risk for cancer development. Methods: A total of 623 consecutive HCV carriers with follow-up periods of >3years were included. The average integration values were calculated from biochemical tests, and tumor markers, including AFP, AFP-L3%, and DCP, and factors associated with the cumulative incidence of HCC were analyzed. Results: HCC developed in 120 (19.3%) of the 623 patients. Age >65years [adjusted relative risk, 2.303 (95% confidence interval, 1.551-3.418), P<0.001], low platelet count [3.086 (1.997-4.768), P<0.001], high aspartate aminotransferase value [3.001 (1.373-6.562), P<0.001], high AFP level [≥10, <20ng/mL: 2.814 (1.686-4.697), P<0.001; ≥20ng/mL: 3.405 (2.087-5.557), P<0.001] compared to <10ng/mL, and high AFP-L3% level [≥5, <10%: 2.494 (1.291-4.816), P=0.007; ≥10%: 3.555 (1.609-7.858), P<0.001] compared to <5% were significantly associated with an increased incidence of HCC on multivariate analysis. Conclusions: Increased AFP or AFP-L3% levels were significantly associated with an increased incidence of HCC. Among HCV carriers, patients with ≥10ng/mL AFP or patients with ≥5% AFP-L3% are at very high risk for the development of HCC even if AFP is less than 20ng/mL or AFP-L3% is less than 10%, which are the most commonly reported cutoff values. Springer, 2010 Alpha-fetoprotein (AFP) nationallicence Lens culinaris agglutinin-reactive fraction of AFP nationallicence Hepatic regeneration nationallicence Necroinflammatory activity nationallicence Hepatocarcinogenesis nationallicence Kumada Takashi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Toyoda Hidenori Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Kiriyama Seiki Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Tanikawa Makoto Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Hisanaga Yasuhiro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Kanamori Akira Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Tada Toshifumi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut Tanaka Junko Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut Yoshizawa Hiroshi Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 536-544 0944-1174 46:4<536 2011 46 535 https://doi.org/10.1007/s00535-010-0349-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0349-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kumada Takashi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Toyoda Hidenori Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Kiriyama Seiki Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Tanikawa Makoto Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Hisanaga Yasuhiro Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Kanamori Akira Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Tada Toshifumi Department of Gastroenterology, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, 503-8052, Ogaki, Gifu, Japan aut NATIONALLICENCE 700 1- Tanaka Junko Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yoshizawa Hiroshi Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 536-544 0944-1174 46:4<536 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer