caa a22 4500 445888822 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00535-010-0358-6 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0358-6 Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C [Elektronische Daten] [Kazuaki Chayama, C. Hayes, Kentaro Yoshioka, Hisataka Moriwaki, Takashi Okanoue, Shotaro Sakisaka, Tetsuo Takehara, Makoto Oketani, Joji Toyota, Namiki Izumi, Yoichi Hiasa, Akihiro Matsumoto, Hideyuki Nomura, Masataka Seike, Yoshiyuki Ueno, Hiroshi Yotsuyanagi, Hiromitsu Kumada] Background: Treatment of genotype 1b chronic hepatitis C virus (HCV) infection has been improved by extending peg-interferon plus ribavirin combination therapy to 72 weeks, but predictive factors are needed to identify those patients who are likely to respond to long-term therapy. Methods: We analyzed amino acid (aa) substitutions in the core protein and the interferon sensitivity determining region (ISDR) of nonstructural protein (NS) 5A in 840 genotype 1b chronic hepatitis C patients with high viral load. We used logistic regression and classification and regression tree (CART) analysis to identify predictive factors for sustained virological response (SVR) for patients undergoing 72 weeks of treatment. Results: When patients were separately analyzed by treatment duration using multivariate logistic regression, several factors, including sex, age, viral load, and core aa70 and ISDR substitutions (P=0.0003, P=0.02, P=0.01, P=0.0001, and P=0.0004, respectively) were significant predictive factors for SVR with 48 weeks of treatment, whereas age, previous interferon treatment history, and ISDR substitutions (P=0.03, P=0.01, and P=0.02, respectively) were the only significant predictive factors with 72 weeks of treatment. Using CART analysis, a decision tree was generated that identified age, cholesterol, sex, treatment length, and aa70 and ISDR substitutions as the most important predictive factors. The CART model had a sensitivity of 69.2% and specificity of 60%, with a positive predictive value of 68.4%. Conclusions: Complementary statistical and data mining approaches were used to identify a subgroup of patients likely to benefit from 72 weeks of therapy. Springer, 2011 CART analysis nationallicence Core protein nationallicence Decision tree nationallicence ISDR nationallicence LDL cholesterol nationallicence HCV : Hepatitis C virus nationallicence ISDR : Interferon sensitivity determining region nationallicence CART : Classification and regression tree analysis nationallicence SVR : Sustained virological response nationallicence NR : Non-viral response nationallicence Chayama Kazuaki Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Hayes C. Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Yoshioka Kentaro Division of Liver, Biliary Tract and Pancreas Diseases, Department of Internal Medicine, Fujita Health University, Nagoya, Japan aut Moriwaki Hisataka Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan aut Okanoue Takashi Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan aut Sakisaka Shotaro Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan aut Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan aut Oketani Makoto Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut Toyota Joji Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan aut Izumi Namiki Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Japan aut Hiasa Yoichi Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Matsuyama, Japan aut Matsumoto Akihiro Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan aut Nomura Hideyuki The Center for Liver Diseases, Shin-Kokura Hospital, Kokura, Japan aut Seike Masataka Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan aut Ueno Yoshiyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Yotsuyanagi Hiroshi Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut Kumada Hiromitsu Department of Hepatology, Toranomon Hospital, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 545-555 0944-1174 46:4<545 2011 46 535 https://doi.org/10.1007/s00535-010-0358-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0358-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chayama Kazuaki Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Hayes C. Department of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yoshioka Kentaro Division of Liver, Biliary Tract and Pancreas Diseases, Department of Internal Medicine, Fujita Health University, Nagoya, Japan aut NATIONALLICENCE 700 1- Moriwaki Hisataka Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan aut NATIONALLICENCE 700 1- Okanoue Takashi Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan aut NATIONALLICENCE 700 1- Sakisaka Shotaro Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Oketani Makoto Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan aut NATIONALLICENCE 700 1- Toyota Joji Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan aut NATIONALLICENCE 700 1- Izumi Namiki Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Japan aut NATIONALLICENCE 700 1- Hiasa Yoichi Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Matsuyama, Japan aut NATIONALLICENCE 700 1- Matsumoto Akihiro Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan aut NATIONALLICENCE 700 1- Nomura Hideyuki The Center for Liver Diseases, Shin-Kokura Hospital, Kokura, Japan aut NATIONALLICENCE 700 1- Seike Masataka Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan aut NATIONALLICENCE 700 1- Ueno Yoshiyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Yotsuyanagi Hiroshi Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kumada Hiromitsu Department of Hepatology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/4(2011-04-01), 545-555 0944-1174 46:4<545 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer