caa a22 4500 445888849 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00535-011-0416-8 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0416-8 Development of corpus atrophic gastritis may be associated with Helicobacter pylori -related idiopathic thrombocytopenic purpura [Elektronische Daten] [Ryugo Sato, Kazunari Murakami, Tadayoshi Okimoto, Koichiro Watanabe, Masaaki Kodama, Toshio Fujioka] Background: A strict correlation between Helicobacter pylori eradication and an increase in platelet count has previously been reported in patients with chronic idiopathic thrombocytopenic purpura (ITP). To clarify the pathogenesis of H. pylori-induced ITP and the factors predicting the platelet response to H. pylori eradication therapy, we evaluated the markers of atrophic gastritis in ITP patients. Methods: The study population comprised 31 H. pylori-infected patients with chronic ITP. After undergoing upper gastrointestinal endoscopy and gastric biopsy, all patients received H. pylori eradication therapy. The effect of H. pylori eradication on the platelet count was evaluated for up to 6-54months after the therapy. The degree of endoscopic gastric atrophy, histological parameters in the gastric mucosa, and serum pepsinogen (PG) levels were compared between platelet responders and nonresponders to the therapy. Results: H. pylori was successfully eradicated in all patients and a platelet response was seen in 18 (58%) of these patients. The serum pepsinogen (PG) I/II ratio at pretreatment was significantly lower in responders than in nonresponders. The degree of endoscopic gastric atrophy was significantly more severe in responders than in nonresponders. Furthermore, the levels of histological parameters of activity, inflammation, and atrophy in the gastric corpus, but not in the gastric antrum, were significantly more severe in responders than in nonresponders,. Conclusion: The development of corpus atrophic gastritis may be a suitable condition for inducing thrombocytopenia. Evaluation of the serum, endoscopic, and histological markers of atrophic gastritis may assist in selecting patients with ITP who are more likely to respond to H. pylori eradication therapy. Springer, 2011 Idiopathic thrombocytopenic purpura nationallicence Helicobacter pylori nationallicence Atrophic gastritis nationallicence Sato Ryugo Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut Murakami Kazunari Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut Okimoto Tadayoshi Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut Watanabe Koichiro Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut Kodama Masaaki Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut Fujioka Toshio Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut Journal of Gastroenterology Springer Japan 46/8(2011-08-01), 991-997 0944-1174 46:8<991 2011 46 535 https://doi.org/10.1007/s00535-011-0416-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0416-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Ryugo Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut NATIONALLICENCE 700 1- Murakami Kazunari Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut NATIONALLICENCE 700 1- Okimoto Tadayoshi Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut NATIONALLICENCE 700 1- Watanabe Koichiro Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut NATIONALLICENCE 700 1- Kodama Masaaki Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut NATIONALLICENCE 700 1- Fujioka Toshio Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, 879-5593, Oita, Yufu, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/8(2011-08-01), 991-997 0944-1174 46:8<991 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer