caa a22 4500 445888865 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00535-011-0415-9 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0415-9 Hepatitis B virus X gene and hepatocarcinogenesis [Elektronische Daten] [Sue-Ann Ng, Caroline Lee] Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The pathogenesis of HBV-mediated hepatocarcinogenesis is, however, incompletely understood. Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development. HBx is a multifunctional regulator that modulates transcription, signal transduction, cell cycle progression, apoptosis, protein degradation pathways, and genetic stability through interaction with host factors. This review describes the current state of knowledge of the molecular pathogenesis of HBV-induced HCC, with a focus on the role of HBx in hepatocarcinogenesis. Springer, 2011 Hepatitis B virus nationallicence HBx nationallicence Hepatocellualar carcinoma nationallicence Hepatocarcinogenesis nationallicence Ng Sue-Ann Faculty of Medicine, University of New South Wales, 2052, Sydney, NSW, Australia aut Lee Caroline Department of Biochemistry, National University of Singapore, MD7, #05-06A, 8 Medical Drive, 117597, Singapore, Singapore aut Journal of Gastroenterology Springer Japan 46/8(2011-08-01), 974-990 0944-1174 46:8<974 2011 46 535 https://doi.org/10.1007/s00535-011-0415-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0415-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ng Sue-Ann Faculty of Medicine, University of New South Wales, 2052, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Lee Caroline Department of Biochemistry, National University of Singapore, MD7, #05-06A, 8 Medical Drive, 117597, Singapore, Singapore aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/8(2011-08-01), 974-990 0944-1174 46:8<974 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer