caa a22 4500 445888881 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00535-011-0409-7 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0409-7 Efficacy of re-treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan [Elektronische Daten] [Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Hiroyuki Fukui, Taizo Hijioka, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Atsushi Hosui, Takuya Miyagi, Hisashi Ishida, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi] Background: It is still not known which patients with chronic hepatitis C who failed to respond to previous pegylated interferon (Peg-IFN) plus ribavirin therapy can benefit from re-treatment. Methods: Seventy-four patients (HCV genotype 1, n=56, genotype 2, n=18) were re-treated with Peg-IFN plus ribavirin. Results: On re-treatment, the sustained virologic response (SVR) rate was 41% for genotype 1 and 56% for genotype 2. With genotype 1, the factors associated with an SVR were previous treatment response and the serum hepatitis C virus (HCV) RNA level at the start of re-treatment. Patients with a ≥2-log decrease in HCV RNA at week 12 (partial early virologic response, p-EVR) in previous treatment had significantly higher SVR rates than those without these decreases (p<0.001); no patient without a p-EVR in the previous treatment attained an SVR with re-treatment (0/16). All patients with <5 log10 IU/ml of HCV RNA at the start of re-treatment attained an SVR (6/6), while only 33% (15/45) of those patients with ≥5 log10 IU/ml of HCV RNA attained an SVR (p<0.01). Among the patients with relapse in the previous treatment, those who attained an SVR on re-treatment required a longer duration of re-treatment than the duration of the previous treatment (re-treatment, 63.8±13.0weeks vs. previous treatment, 53.9±13.5weeks, p=0.01). Conclusions: Re-treatment of genotype 1 patients should be limited to patients with a p-EVR in the previous treatment and a low HCV RNA level at the start of re-treatment. In re-treatment with Peg-IFN plus ribavirin, longer treatment duration can contribute to increasing the anti-viral effect. Springer, 2011 Chronic hepatitis C nationallicence Pegylated interferon and ribavirin combination therapy nationallicence Re-treatment nationallicence Oze Tsugiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yakushijin Takayuki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Mochizuki Kiyoshi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Oshita Masahide Osaka Police Hospital, Osaka, Japan aut Hagiwara Hideki Kansai Rousai Hospital, Amagasaki, Japan aut Mita Eiji National Hospital Organization Osaka National Hospital, Osaka, Japan aut Ito Toshifumi Osaka Koseinenkin Hospital, Osaka, Japan aut Inui Yoshiaki Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan aut Fukui Hiroyuki Yao Municipal Hospital, Osaka, Japan aut Hijioka Taizo National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan aut Katayama Kazuhiro Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Tamura Shinji Minoh City Hospital, Minoh, Japan aut Yoshihara Harumasa Osaka Rousai Hospital, Sakai, Japan aut Inoue Atsuo Osaka General Medical Center, Osaka, Japan aut Imai Yasuharu Ikeda Municipal Hospital, Ikeda, Japan aut Hayashi Eijiro Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami, Japan aut Kato Michio National Hospital Organization Minami Wakayama Medical Center, Tanabe, Japan aut Hosui Atsushi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Miyagi Takuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Ishida Hisashi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Tatsumi Tomohide Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kanto Tatsuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kasahara Akinori Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut Hayashi Norio Kansai Rousai Hospital, Amagasaki, Japan aut Journal of Gastroenterology Springer Japan 46/8(2011-08-01), 1031-1037 0944-1174 46:8<1031 2011 46 535 https://doi.org/10.1007/s00535-011-0409-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0409-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oze Tsugiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yakushijin Takayuki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Mochizuki Kiyoshi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Oshita Masahide Osaka Police Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Hagiwara Hideki Kansai Rousai Hospital, Amagasaki, Japan aut NATIONALLICENCE 700 1- Mita Eiji National Hospital Organization Osaka National Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Ito Toshifumi Osaka Koseinenkin Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Inui Yoshiaki Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Fukui Hiroyuki Yao Municipal Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Hijioka Taizo National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan aut NATIONALLICENCE 700 1- Katayama Kazuhiro Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Tamura Shinji Minoh City Hospital, Minoh, Japan aut NATIONALLICENCE 700 1- Yoshihara Harumasa Osaka Rousai Hospital, Sakai, Japan aut NATIONALLICENCE 700 1- Inoue Atsuo Osaka General Medical Center, Osaka, Japan aut NATIONALLICENCE 700 1- Imai Yasuharu Ikeda Municipal Hospital, Ikeda, Japan aut NATIONALLICENCE 700 1- Hayashi Eijiro Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami, Japan aut NATIONALLICENCE 700 1- Kato Michio National Hospital Organization Minami Wakayama Medical Center, Tanabe, Japan aut NATIONALLICENCE 700 1- Hosui Atsushi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Miyagi Takuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ishida Hisashi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Tatsumi Tomohide Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kanto Tatsuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kasahara Akinori Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hayashi Norio Kansai Rousai Hospital, Amagasaki, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/8(2011-08-01), 1031-1037 0944-1174 46:8<1031 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer