caa a22 4500 445888962 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00535-011-0382-1 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0382-1 Survey on the prevalence of GERD and FD based on the Montreal definition and the Rome III criteria among patients presenting with epigastric symptoms in Japan [Elektronische Daten] [Shuichi Ohara, Tatsuyuki Kawano, Motoyasu Kusano, Teruo Kouzu] Background: The present survey aimed to clarify the prevalence of gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) in patients presenting with epigastric symptoms in Japan based on the Montreal definition and the Rome III criteria, respectively, and to determine the degree of overlap between the two disease entities and the validity of using these Western-developed diagnostic criteria in Japan. Methods: Patients presenting with epigastric symptoms for whom the first upper gastrointestinal endoscopy was scheduled from April through August 2007 at 55 institutions were asked to complete a questionnaire to ascertain the type, frequency, and severity of epigastric symptoms. The prevalence of esophageal mucosal damage was also determined from endoscopic findings. Results: A total of 1,076 patients were included in the analysis population. There was a high degree of coincidence for all symptoms, with the mean number of symptoms per patient of 2.8. With strict application of the Montreal and Rome III definitions, symptomatic GERD accounted for 15.6% (168 patients), whereas FD accounted for 10.3% (111 patients), and the overlap between GERD and FD symptoms was less than 10%. However, when frequency and severity alone were considered in more broadly defined criteria, the overlap between GERD and FD symptoms was 30-40%. Conclusion: A highly specific disease classification is possible when the Montreal definition and the Rome III criteria are strictly applied. On the other hand, the present survey highlighted a problem with the criteria whereby a definitive diagnosis could not be made in a substantial number of patients. This problem will require further research. Springer, 2011 GERD nationallicence FD nationallicence Montreal definition nationallicence Rome III criteria nationallicence Epigastric symptoms nationallicence Ohara Shuichi Department of Gastroenterology, Tohoku Rosai Hospital, 4-3-21 Dainohara, Aoba-ku, 981-8563, Sendai, Miyagi, Japan aut Kawano Tatsuyuki Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan aut Kusano Motoyasu Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan aut Kouzu Teruo Department of Endoscopic Diagnostics and Therapeutics, Chiba University Hospital, Chiba, Japan aut Journal of Gastroenterology Springer Japan 46/5(2011-05-01), 603-611 0944-1174 46:5<603 2011 46 535 https://doi.org/10.1007/s00535-011-0382-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0382-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohara Shuichi Department of Gastroenterology, Tohoku Rosai Hospital, 4-3-21 Dainohara, Aoba-ku, 981-8563, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Kawano Tatsuyuki Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kusano Motoyasu Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan aut NATIONALLICENCE 700 1- Kouzu Teruo Department of Endoscopic Diagnostics and Therapeutics, Chiba University Hospital, Chiba, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/5(2011-05-01), 603-611 0944-1174 46:5<603 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer