caa a22 4500 445889055 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00535-011-0385-y doi (NATIONALLICENCE)springer-10.1007/s00535-011-0385-y Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy [Elektronische Daten] [Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Wataru Iwai, Kaname Uno, Naoki Asano, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa] Background: The relative contribution of gastric acid secretion and Helicobacter pylori infection to low-dose aspirin-induced gastropathy remains to be clarified. This is partly because the capability of the infection to modify gastric acid secretion complicates the interaction. The aim of this study was to estimate the association of aspirin-induced mucosal injury, as well as H. pylori infection, with gastric acid output. Methods: A total of 186 male outpatients, comprising 60 aspirin takers, on 100mg of enteric-coated aspirin daily and 126 non-aspirin takers were prospectively enrolled in this study. Gastrin-stimulated acid output was estimated by the endoscopic gastrin test. The grade of gastric mucosal injury was assessed endoscopically according to the modified Lanza score. Multiple logistic regression analyses were used to adjust for potential confounders. Results: The gastric acid secretion level, with an odds ratio (OR) (95% confidence interval [CI]) of 10.5 (3.0-36.9) and aspirin administration, with an OR (95% CI) of 7.4 (3.0-18.3) were independently associated with gastric mucosal injury, and the co-existence of both factors greatly elevated the risk of mucosal injury, with an OR (95% CI) of 77.0 (13.5-440.0). H. pylori infection, itself, did not show any significant effect on the aspirin-induced mucosal injury after adjusting for gastric acid secretion. Conclusions: This study has demonstrated that aspirin-induced gastropathy is directly associated with gastric acid secretion. In addition, it also suggested that the gastric acid secretion level modulates the association between H. pylori infection and aspirin-induced gastropathy. Springer, 2011 Aspirin nationallicence Gastric acid secretion nationallicence Gastric mucosal injury nationallicence H. pylori nationallicence CI : Confidence interval nationallicence EGT : Endoscopic gastrin test nationallicence GI : Gastrointestinal nationallicence MLS : Modified Lanza score nationallicence NSAID : Non-steroidal anti-inflammatory drug nationallicence OR : Odds ratio nationallicence PPI : Proton pump inhibitor nationallicence Iijima Katsunori Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Ara Nobuyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Abe Yasuhiko Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Koike Tomoyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Iwai Wataru Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Uno Kaname Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Asano Naoki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Imatani Akira Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Ohara Shuichi Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Shimosegawa Tooru Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut Journal of Gastroenterology Springer Japan 46/5(2011-05-01), 612-619 0944-1174 46:5<612 2011 46 535 https://doi.org/10.1007/s00535-011-0385-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0385-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iijima Katsunori Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Ara Nobuyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Abe Yasuhiko Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Koike Tomoyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Iwai Wataru Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Uno Kaname Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Asano Naoki Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Imatani Akira Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Ohara Shuichi Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Shimosegawa Tooru Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/5(2011-05-01), 612-619 0944-1174 46:5<612 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer