caa a22 4500 445889071 CHVBK 20180317145609.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00535-010-0365-7 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0365-7 New method for assessing liver fibrosis based on acoustic radiation force impulse: a special reference to the difference between right and left liver [Elektronische Daten] [Takeo Toshima, Ken Shirabe, Kazuki Takeishi, Takashi Motomura, Youhei Mano, Hideaki Uchiyama, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara] Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61±0.51 and 1.90±0.68, respectively, and the difference was statistically significant (P<0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P<0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P<0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe. Springer, 2011 Virtual touch tissue quantification nationallicence Acoustic radiation force impulse nationallicence Liver fibrosis nationallicence Transient elastography nationallicence Chronic hepatitis nationallicence VTTQ : Virtual Touch™ tissue quantification nationallicence ARFI : Acoustic radiation force impulse nationallicence ROC : Receiver operating characteristic nationallicence ALT : Alanine aminotransferase nationallicence LDLT : Living donor liver transplantation nationallicence APRI : Aspartate transaminase-to-platelet ratio index nationallicence HCVAb : Hepatitis C virus antibody nationallicence HBsAg : Hepatitis B virus surface antigen nationallicence m/s : Meters per second nationallicence AST : Aspartate aminotransferase nationallicence PPV : Positive predictive value nationallicence NPV : Negative predictive value nationallicence HBV : Hepatitis B virus nationallicence HCV : Hepatitis C virus nationallicence Toshima Takeo Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Shirabe Ken Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Takeishi Kazuki Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Motomura Takashi Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Mano Youhei Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Uchiyama Hideaki Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Yoshizumi Tomoharu Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Soejima Yuji Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Taketomi Akinobu Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Maehara Yoshihiko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut Journal of Gastroenterology Springer Japan 46/5(2011-05-01), 705-711 0944-1174 46:5<705 2011 46 535 https://doi.org/10.1007/s00535-010-0365-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0365-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toshima Takeo Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Shirabe Ken Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takeishi Kazuki Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Motomura Takashi Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Mano Youhei Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Uchiyama Hideaki Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yoshizumi Tomoharu Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Soejima Yuji Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Taketomi Akinobu Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Maehara Yoshihiko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/5(2011-05-01), 705-711 0944-1174 46:5<705 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE 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