caa a22 4500 445889128 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00535-010-0321-6 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0321-6 Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome [Elektronische Daten] [Hong-Yan Qin, Justin Wu, Xu-Dong Tong, Joseph Sung, Hong-Xi Xu, Zhao-Xiang Bian] Aims: Post-infectious irritable bowel syndrome (PI-IBS) is a subset of IBS which occurs after an episode of acute gastrointestinal infections. The mechanisms of PI-IBS are not fully understood. Currently, numerous animal models have been used in the study of PI-IBS. This article reviews the strengths and weaknesses of these models. Methods: All relevant articles were identified by searching in Ovid SP from 1962, the year the term PI-IBS was coined, up to December 31, 2009. The types of model were categorized as either post-infectious or post-inflammatory, and the characteristics of each kind of model were listed. Results: Based on our literature search, 268 articles were identified. Of those articles, 50 were included in this review. The existing PI-IBS models include infection with bacteria (e.g., Campylobacter jejuni, Salmonella enterica, and Campylobacter rodentium), and infection with parasites (e.g., Trichinella spiralis, Nippostrongylus brasiliensis, and Cryptosporidium parvum). The post-inflammatory IBS models are commonly induced with chemical agents, such as acetic acid, deoxycholic acid, dextran sulfate sodium, mustard oil, zymosan, and trinitrobenzene sulfonic acid (TNBS). TNBS is the most commonly used agent for post-inflammatory IBS models, but the experimental protocol varies. These models have one or more aspects similar to IBS patients. Conclusions: Different methods have been used for the development of post-infectious or post-inflammatory IBS models. Each model has its weaknesses and strengths. More studies are needed to establish post-infection IBS models using more common pathogens. A standard protocol in developing TNBS-induced post-inflammatory IBS model is needed. Springer, 2010 Post-infection nationallicence Post-inflammation nationallicence Animal model nationallicence Irritable bowel syndrome nationallicence Qin Hong-Yan School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China aut Wu Justin Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Tong Xu-Dong China Academy of Chinese Medical Sciences, Beijing, China aut Sung Joseph Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Xu Hong-Xi Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China aut Bian Zhao-Xiang School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China aut Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 164-174 0944-1174 46:2<164 2011 46 535 https://doi.org/10.1007/s00535-010-0321-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0321-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qin Hong-Yan School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China aut NATIONALLICENCE 700 1- Wu Justin Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Tong Xu-Dong China Academy of Chinese Medical Sciences, Beijing, China aut NATIONALLICENCE 700 1- Sung Joseph Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Xu Hong-Xi Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China aut NATIONALLICENCE 700 1- Bian Zhao-Xiang School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 164-174 0944-1174 46:2<164 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer