caa a22 4500 445889136 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00535-010-0341-2 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0341-2 Characteristics of recurrence after curative resection for T1 colorectal cancer: Japanese multicenter study [Elektronische Daten] [Hirotoshi Kobayashi, Hidetaka Mochizuki, Takayuki Morita, Kenjiro Kotake, Tatsuo Teramoto, Shingo Kameoka, Yukio Saito, Keiichi Takahashi, Kazuo Hase, Masatoshi Oya, Koutarou Maeda, Takashi Hirai, Masao Kameyama, Kazuo Shirouzu, Kenichi Sugihara] Background: Because the rate of recurrence after curative resection for T1 colorectal cancer is low, the characteristics of recurrence remain obscure. This multicenter study attempted to clarify the characteristics of recurrence after curative resection for T1 colorectal cancer. Methods: We analyzed the associations between recurrence and various clinicopathological features in 798 patients who had undergone curative resection alone for T1 colorectal cancer at 14 hospitals between 1991 and 1996. Results: The rate of lymph node metastasis (LNM) in patients with T1 colorectal cancer was 10.5% (84/798), and 18 (2.3%) of the 798 patients developed recurrence during the median follow-up of 7.8years. The recurrence rates in patients with colon cancer with and without LNM were 3.6 and 1.3%, respectively (p=0.19). These rates in patients with cancer of the rectum were 25.0 and 1.1% (p<0.0001). Among various parameters, histological grade (p<0.0001), location (p=0.025), LNM (p<0.0001), and venous invasion (p=0.0013) were risk factors for recurrence. Among them, LNM (p=0.0008) and histological grade (p=0.041) were independent risk factors for recurrence after curative resection for T1 colorectal cancer. Time to recurrence was more likely to be shorter for patients with, than without nodal involvement. In patients with an unfavorable histological grade, all recurrences developed within 1year. Conclusions: The recurrence rate after curative resection for node-negative T1 colorectal cancer was very low. The effectiveness of surveillance to detect recurrence after curative resection for T1 colorectal cancer should be validated in further studies. Springer, 2010 Lymph node metastasis nationallicence Lymph node ratio nationallicence Venous invasion nationallicence Histological grade nationallicence Relapse nationallicence Kobayashi Hirotoshi Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut Mochizuki Hidetaka Department of Surgery, National Defense Medical College, Tokorozawa, Japan aut Morita Takayuki Department of Surgery, School of Medicine, Hirosaki University, Hirosaki, Japan aut Kotake Kenjiro Department of Surgery, Tochigi Cancer Center, Tochigi, Japan aut Teramoto Tatsuo Division of General and Gastroenterological Surgery, Department of Surgery (Omori), School of Medicine, Toho University, Tokyo, Japan aut Kameoka Shingo Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan aut Saito Yukio Department of Surgery, International Medical Center of Japan, Tokyo, Japan aut Takahashi Keiichi Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut Hase Kazuo Department of Surgery, Self-Defense Forces Central Hospital, Tokyo, Japan aut Oya Masatoshi Department of Surgery, Cancer Institute Hospital, Tokyo, Japan aut Maeda Koutarou Department of Surgery, Fujita Health University, Toyoake, Japan aut Hirai Takashi Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan aut Kameyama Masao Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Shirouzu Kazuo Department of Surgery, Kurume University School of Medicine, Kurume, Japan aut Sugihara Kenichi Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 203-211 0944-1174 46:2<203 2011 46 535 https://doi.org/10.1007/s00535-010-0341-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0341-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobayashi Hirotoshi Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut NATIONALLICENCE 700 1- Mochizuki Hidetaka Department of Surgery, National Defense Medical College, Tokorozawa, Japan aut NATIONALLICENCE 700 1- Morita Takayuki Department of Surgery, School of Medicine, Hirosaki University, Hirosaki, Japan aut NATIONALLICENCE 700 1- Kotake Kenjiro Department of Surgery, Tochigi Cancer Center, Tochigi, Japan aut NATIONALLICENCE 700 1- Teramoto Tatsuo Division of General and Gastroenterological Surgery, Department of Surgery (Omori), School of Medicine, Toho University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kameoka Shingo Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Yukio Department of Surgery, International Medical Center of Japan, Tokyo, Japan aut NATIONALLICENCE 700 1- Takahashi Keiichi Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Hase Kazuo Department of Surgery, Self-Defense Forces Central Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Oya Masatoshi Department of Surgery, Cancer Institute Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Maeda Koutarou Department of Surgery, Fujita Health University, Toyoake, Japan aut NATIONALLICENCE 700 1- Hirai Takashi Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan aut NATIONALLICENCE 700 1- Kameyama Masao Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Shirouzu Kazuo Department of Surgery, Kurume University School of Medicine, Kurume, Japan aut NATIONALLICENCE 700 1- Sugihara Kenichi Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 203-211 0944-1174 46:2<203 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer